Millipore Sigma Vibrant Logo

219334 β-Catenin/Tcf Inhibitor V, BC21 - CAS 691005-38-6 - Calbiochem

The β-Catenin/Tcf Inhibitor V, BC21, also referenced under CAS 691005-38-6, controls the biological activity of β-Catenin/Tcf. This small molecule/inhibitor is primarily used for Biochemicals applications.

β-Catenin/Tcf Inhibitor V, BC21 - CAS 691005-38-6 - Calbiochem: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: Copper, di-µ-chlorobis[1-[(1-piperidinyl-κN)methyl]-2-naphthalenolato-κO]di-(9Cl), Wnt Pathway Inhibitor XV

219334
価格＆在庫状況を照会

概要

Replacement Information

主要スペック表

CAS #Empirical Formula
691005-38-6C₃₂H₃₆Cl₂Cu₂N₂O₂

価格＆在庫状況

カタログ番号 在庫状況包装 Qty/Pk 価格 数量
219334-10MGCN
在庫状況検索中…
—
現在国内在庫なし 現在国内在庫なし
現在国内在庫有り 
販売中止
在庫僅少
現在国内在庫あり
    Remaining : Will advise
      Remaining : Will advise
      注文対象外
      お問合せください
      Contact Customer Service

      		 ｶﾞﾗｽﾋﾞﾝ 10 mg
      価格を検索中…
      価格が見つかりません
      Minimum Quantity needs to be mulitiple of
      Maximum Quantity is
      弊社照会 詳細を表示　
      値引
      ()
       
      —
      弊社照会
      		 —
      Description
      OverviewA cell-permeable dimeric copper complex that competitively binds β-catenin and disrupts β-catenin/Tcf4 interaction reversibly (IC50 = 5.0 µM), and acts as a Wnt signaling inhibitor. Shown to induce preferential growth arrest in β-catenin overexpressing HCT116 colon cancer and HEK293 cells (≤ 10 µM), and downregulate mRNA expressions of c-Myc and cyclin D1. Reported to inhibit PP2C and proteasomal activities at higher concentrations (~50 µM).
      Catalogue Number219334
      Brand Family Calbiochem®
      SynonymsCopper, di-µ-chlorobis[1-[(1-piperidinyl-κN)methyl]-2-naphthalenolato-κO]di-(9Cl), Wnt Pathway Inhibitor XV
      References
      ReferencesTian, W., et al. 2012. Biochemistry 51, 724.
      Rogers, J.P., et al. 2006. J. Med. Chem. 49, 1658.
      Daniel, K.G., et al. 2004. Biochem. Pharmacol. 67, 1139.
      Product Information
      CAS number691005-38-6
      FormDark brown solid
      Hill FormulaC₃₂H₃₆Cl₂Cu₂N₂O₂
      Chemical formulaC₃₂H₃₆Cl₂Cu₂N₂O₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by Elemental Analysis
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot, freeze (≥-70°C). Stock solutions are stable for up to 12 months at ≥-70°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      219334-10MGCN 04055977202137

      Documentation

      β-Catenin/Tcf Inhibitor V, BC21 - CAS 691005-38-6 - Calbiochem (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      β-Catenin/Tcf Inhibitor V, BC21 - CAS 691005-38-6 - Calbiochem 試験成績書（CoA）

      タイトルロット番号
      219334

      参考資料

      参考資料の概要
      Tian, W., et al. 2012. Biochemistry 51, 724.
      Rogers, J.P., et al. 2006. J. Med. Chem. 49, 1658.
      Daniel, K.G., et al. 2004. Biochem. Pharmacol. 67, 1139.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-February-2017 JSW
      SynonymsCopper, di-µ-chlorobis[1-[(1-piperidinyl-κN)methyl]-2-naphthalenolato-κO]di-(9Cl), Wnt Pathway Inhibitor XV
      DescriptionA cell-permeable dimeric copper complex that competitively binds β-catenin and disrupts β-catenin/Tcf4 interaction reversibly (IC50 = 5.0 µM), and acts as a Wnt signaling inhibitor. Shown to induce preferential growth arrest in β-catenin overexpressing HCT116 colon cancer and HEK293 cells (≤ 10 µM), and downregulate mRNA expressions of c-Myc and cyclin D1. Reported to inhibit PP2C and proteasomal activities at higher concentrations (~50 µM).
      FormDark brown solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number691005-38-6
      Chemical formulaC₃₂H₃₆Cl₂Cu₂N₂O₂
      Structure formulaStructure formula
      Purity≥95% by Elemental Analysis
      SolubilityDMSO (0.5 mg/ml). Poorly soluble in water.
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot, freeze (≥-70°C). Stock solutions are stable for up to 12 months at ≥-70°C.
      Toxicity Standard Handling
      ReferencesTian, W., et al. 2012. Biochemistry 51, 724.
      Rogers, J.P., et al. 2006. J. Med. Chem. 49, 1658.
      Daniel, K.G., et al. 2004. Biochem. Pharmacol. 67, 1139.