Millipore Sigma Vibrant Logo

219333 β-Catenin/Tcf Inhibitor IV

A cell-permeable, potent inhibitor of Tcf4-luciferase expression in both 33.13 and 22C11 cells (IC₅₀ = 596, 690 nM, respectively). Arrests the growth of colon cancer cells.

β-Catenin/Tcf Inhibitor IV: のSDS（安全データシート）、CoA（試験成績書）およびCoQ（品質証明書）、カタログなど製品関連の技術資料を入手いただけます。

同義語: 6-Chloro-N-(4-(((2-(methylamino)quinazolin-4-yl)amino)methyl)phenyl)nicotinamide, Wnt Pathway Inhibitor XVIII

219333
価格＆在庫状況を照会

概要

Replacement Information

主要スペック表

Empirical Formula
C₂₂H₁₉ClN₆O

価格＆在庫状況

カタログ番号 在庫状況包装 Qty/Pk 価格 数量
219333-5MGCN
在庫状況検索中…
—
現在国内在庫なし 現在国内在庫なし
現在国内在庫有り 
販売中止
在庫僅少
現在国内在庫あり
    Remaining : Will advise
      Remaining : Will advise
      注文対象外
      お問合せください
      Contact Customer Service

      		 ｶﾞﾗｽﾋﾞﾝ 5 mg
      価格を検索中…
      価格が見つかりません
      Minimum Quantity needs to be mulitiple of
      Maximum Quantity is
      弊社照会 詳細を表示　
      値引
      ()
       
      —
      弊社照会
      		 —
      Description
      OverviewA cell-permeable diaminoquinazoline compound that potently inhibits Tcf4-luciferase expression in both 33.13 and 22C11 cells and only minimally affects 5A8 control cells (IC50 = 596, 690 and > 2984 nM, respectively), and arrests the growth of 33.13, HT29, DLD1 and LoVo colon cancer cells (IC50 = 648, 1375, 1739 and 1400 nM, respectively). Displays moderate solubility (23 µg/ml at pH 7.4) and microsomal stability in rat (t1/2 = 17 mins), exerts preferential antiproliferative effect towards activated β-catenin signaling over K-ras in a RK3E differential adherent assay (K-ras/β-Cat ~ 2.8) and suppresses the in vivo growth of a β-catenin/RK3E tumor xenograft in nude mice (19 mg/kg, i.p.). Shown to alter the gene expression levels of several cyclins, phosphatases and transcription factors and overlap with the siRNA knockdown of β-catenin or Tcf4 profile in HT29 cells.
      Catalogue Number219333
      Brand Family Calbiochem®
      Synonyms6-Chloro-N-(4-(((2-(methylamino)quinazolin-4-yl)amino)methyl)phenyl)nicotinamide, Wnt Pathway Inhibitor XVIII
      References
      ReferencesDehnhardt, C.M., et al. 2010. J. Med. Chem. 53, 897.
      Product Information
      FormOff-white solid
      Hill FormulaC₂₂H₁₉ClN₆O
      Chemical formulaC₂₂H₁₉ClN₆O
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      カタログ番号 GTIN
      219333-5MGCN 04055977202120

      Documentation

      β-Catenin/Tcf Inhibitor IV (M)SDS

      タイトル

      英語版製品安全データシート（(M)SDS） 

      β-Catenin/Tcf Inhibitor IV 試験成績書（CoA）

      タイトルロット番号
      219333

      参考資料

      参考資料の概要
      Dehnhardt, C.M., et al. 2010. J. Med. Chem. 53, 897.
      データシート

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision21-March-2014 JSW
      Synonyms6-Chloro-N-(4-(((2-(methylamino)quinazolin-4-yl)amino)methyl)phenyl)nicotinamide, Wnt Pathway Inhibitor XVIII
      DescriptionA cell-permeable diaminoquinazoline compound that potently inhibits Tcf4-luciferase expression in both 33.13 and 22C11 cells and only minimally affects 5A8 control cells (IC50 = 596, 690 and > 2984 nM, respectively), and arrests the growth of 33.13, HT29, DLD1 and LoVo colon cancer cells (IC50 = 648, 1375, 1739 and 1400 nM, respectively). Displays moderate solubility (23 µg/ml at pH 7.4) and microsomal stability in rat (t1/2 = 17 mins), exerts preferential antiproliferative effect towards activated β-catenin signaling over K-ras in a RK3E differential adherent assay (K-ras/β-Cat ~ 2.8) and suppresses the in vivo growth of a β-catenin/RK3E tumor xenograft in nude mice (19 mg/kg, i.p.). Shown to alter the gene expression levels of several cyclins, phosphatases and transcription factors and overlap with the siRNA knockdown of β-catenin or Tcf4 profile in HT29 cells.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₂H₁₉ClN₆O
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesDehnhardt, C.M., et al. 2010. J. Med. Chem. 53, 897.