Millipore Sigma Vibrant Logo
 

MILLIPLEX MAP使用文献

MILLIPLEX MAPは研究領域別に分類されたパネル群と、それらに含まれる計900種以上のアナライトによって、マルチプレックスアッセイをサポートしています。
組み合わせが多様に亘るため、各パネルの使用実績や各種研究でどのようなアナライトが実際に使用されているのか、また、製品プロトコールに記載されている適用サンプル以外のサンプルでも測定は可能かどうか知りたい、という声を多数いただいていました。

本ページでは、そのようなご要望にお応えして、MILLIPLEX MAPが使用された文献の一部を「研究領域パネル」「疾患別」「特殊サンプル」のカテゴリに分けて紹介しています。
ご購入時やご使用の際に、是非ご参照・ご活用ください。


I. 研究領域パネル別での使用例

1. サイトカインパネル
HCYTOMAG-60K / Human Cytokine/Chemokine Magnetic Bead Panel

Koga T, Migita K, Sato S, et al. Multiple Serum Cytokine Profiling to Identify Combinational Diagnostic Biomarkers in Attacks of Familial Mediterranean Fever [J]. Medicine (Baltimore). 2016 Apr;95(16):e3449. (PMID: 27100444) [使用アナライト]
IL-1β, IL-1RA, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12 (p40), IL-12 (p70), IL-17/IL-17A, IL-18, TNF-α, IFN-α, IFN-γ, G-CSF, sCD54, sCD106, FGF2, CCL2/MCP-1, CCL3/MIP-1α, CCL4/MIP-1β, MDC/CCL22, CXCL1/GRO, CXCL10/IP-10, CX3CL1/ fractalkine.

Kawasumi H, Gono T, Tanaka E, et al. Clinical Characteristics and Cytokine Profiles of Organizing Pneumonia in Patients with Rheumatoid Arthritis Treated with or without Biologics [J]. J Rheumatol. 2016 Apr;43(4):738-44. (PMID: 26834212) [使用アナライト]
IFN-α, IFN-γ, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-13, IL-17/IL-17A, IP-10, TNF-α

Saben J, Lindsey F, Zhong Y, et al. Maternal obesity is associated with a lipotoxic placental environment [J]. Placenta 2014 Mar;35(3):171-7. (PMID: 24484739) [使用アナライト] IL-6, TNF-α

Nakagome K, Bochkov YA, Ashraf S, et al. Effects of rhinovirus species on viral replication and cytokine production [J]. The Journal of allergy and clinical immunology 134 332-341.e10 2014. ( PMID: 24636084) [使用アナライト] CCL5/RANTES, CXCL8/IL-8, CXCL10/IP-10, CXCL11/ Eotaxin, IFN-α2, IFN-β, IFN-λ1, IL-6

Ikeda A, Schwartz J, Peters JL, et al. Pessimistic orientation in relation to telomere length in older men: the VA normative aging study [J]. The Journal of allergy and clinical immunology 134 332-341.e10 2014. ( PMID: 24636503) [使用アナライト] IL-6

HSTCMAG-28SK / Human High Sensitivity T Cell Magnetic Bead Panel

Jiang Y, Wu SH, Shu XO, et al. Cruciferous vegetable intake is inversely correlated with circulating levels of proinflammatory markers in women [J]. Journal of the Academy of Nutrition and Dietetics 114 700-8.e2 2014. (PMID: 24630682) [使用アナライト] TNF-α, IL-1β, IL-6.

MCYTOMAG-70K / Mouse Cytokine/Chemokine Magnetic Bead Panel

Tanaka J, Tanaka H, Mizuki N, et al. Semaphorin 3A controls allergic and inflammatory responses in experimental allergic conjunctivitis [J]. Int J Ophthalmol. 2015 Feb 18;8(1):1-10.(PMID: 25709899) [使用アナライト] IL-5, IL-13, IL-4, IFN-γ, IL-17, TNF-α, IL-10

Dinel AL, André C, Aubert A, et al. Lipopolysaccharide-induced brain activation of the indoleamine 2,3-dioxygenase and depressive-like behavior are impaired in a mouse model of metabolic syndrome[J]. Psychoneuroendocrinology 40 48-59 2014. (PMID: 24485475) [使用アナライト] IL-1β, IL-6, TNF-α, IFN -γ, IL-10

Toraya-Brown S, Sheen MR, Zhang P, et al. Local hyperthermia treatment of tumors induces CD8(+) T cell-mediated resistance against distal and secondary tumors[J]. Nanomedicine : nanotechnology, biology, and medicine 10 1273-85 2014. (PMID: 24566274) [使用アナライト]
Eotaxin/CCL11, G-CSF, GM-CSF, IFN-γ, IL-1α, IL-1β, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-9, IL-10, IL-12 (p40), IL-12 (p70), IL-13, IL-15, IL-17, IP-10/CXCL10, KC-like LIF, LIX, MCP-1, M-CSF, MIG/CXCL9, MIP-1α, MIP-1β, MIP-2, RANTES, TNF-α, VEGF

Sprague L, Muccioli M, Pate M, et al. Dendritic cells: In vitro culture in two- and three-dimensional collagen systems and expression of collagen receptors in tumors and atherosclerotic microenvironments [J]. Experimental cell research 323 7-27 2014. (PMID: 24569142) [使用アナライト] IL-1α, IL-4, IL-6, IL-10, IL-12 (p70), TNF-α

MECY2MAG-73K / Mouse Cytokine/Chemokine Magnetic Bead Panel II, MMMP2MAG-79K / Mouse MMP Panel 2

Ikezoe K, Oga T, Honda T, et al. Aquaporin-3 potentiates allergic airway inflammation in ovalbumin-induced murine asthma [J].Sci Rep. 2016 May 11;6:25781. (PMID: 27165276) [使用アナライト]
MECY2MAG-73K : TARC/CCL17, MDC/CCL22
MMMP2MAG-79K : proMMP-9

PRCYTOMAG-40K / Non-Human Primate Cytokine Magnetic Bead Panel

Shichinohe S, Itoh Y, Nakayama M, et al. Multiple Comparison of pathogenicities of H7 avian influenza viruses via intranasal and conjunctival inoculation in cynomolgus macaques [J].Virology. 2016 Jun;493:31-8.(PMID: 26994587) [使用アナライト] IL-1β, IL-6, IL-8, MIP-1α, MIP-1β, TNF-α, MCP-1

Ramesh G, Santana-Gould L, Inglis FM, et al. The Lyme disease spirochete Borrelia burgdorferi induces inflammation and apoptosis in cells from dorsal root ganglia [J]. Journal of neuroinflammation, 2013 Jul 18;10:88. (PMID: 23866773). [使用アナライト]
G-CSF, GM-CSF, IFN-γ, IL-10, IL-12/23 (p40), IL-13, IL-15, IL-17, IL-18, IL-1ra, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, MCP-1/CCL2, MIP-1α/CCL3, MIP-1β/CCL4, TGF-α, TNF-α, VEGF , sCD40L

2.代謝パネル
RPTMAG-86K / Rat Pituitary Magnetic Bead Panel

Roper L K, Briguglio J S, Evans C S, et al. Sex-specific regulation of follicle-stimulating hormone secretion by synaptotagmin 9[J]. Nature communications, 2015, 6:8645 (IF=11.47) . (PMID: 26482442). [使用アナライト] FSH, LH, GH

MMHMAG-44K / Mouse Metabolic Hormone Magnetic Bead Panel

Ghamari-Langroudi M, Digby G J, Sebag J A, et al. G-protein-independent coupling of MC4R to Kir7. 1 in hypothalamic neurons[J]. Nature, 2015. 520: 94–98 (IF=41.456). (PMID: 25600267). [使用アナライト] total PYY

HMHEMAG-34K / Human Metabolic Hormone Magnetic Bead Panel

Hall K D, Bemis T, Brychta R, et al. Calorie for Calorie, Dietary Fat Restriction Results in More Body Fat Loss than Carbohydrate Restriction in People with Obesity[J]. Cell metabolism, 2015, 22(3): 427-436. (IF=17.565). (PMID: 26278052). [使用アナライト]
ghrelin (active), GLP-1 (active), pancreatic polypeptide, PYY(total), leptin, MCP-1, c-peptide, insulin, GIP(total)

3.シグナリングパネル
46-667MAG / GAPDH Total Magnetic Bead MAPmate

Dhruv HD, Whitsett TG, Jameson NM, et al. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) promotes glioblastoma cell chemotaxis via Lyn activation
[J]. Carcinogenesis. 2014 Jan;35(1):218-26. (PMID: 23975833).
[使用アナライト] GAPDH(total)

48-660MAG / MAPK/SAPK Signaling 10-Plex Kit

Kano G, Almanan M, Bochner BS, et al. Mechanism of Siglec-8-mediated cell death in IL-5-activated eosinophils: role for reactive oxygen species-enhanced MEK/ERK activation
[J].J Allergy Clin Immunol. 2013 Aug;132(2):437-45. (PMID: 23684072).
[使用アナライト]
MEK1 (Ser222), Erk (Thr185/Tyr187), MSK1 (Ser212), STAT1 (Tyr707), p38 (Thr180/Tyr182), JNK (Thr183/Tyr185), HSP27 (Ser78), ATF2 (Thr71), p53 (Ser15), c-Jun (Ser73)

48-680MAG / Multi-Pathway Magnetic Bead 9-Plex

Tisato V, Norcio A, Celeghini C, et al. Upregulation of SOCS-1 by Nutlin-3 in acute myeloid leukemia cells but not in primary normal cells [J].Clinics (Sao Paulo). 2014 Jan;69(1):68-74.(PMID: 24473562). [使用アナライト]
CREB (pS133), ERK (pT185/pY187), NFκB (pS536), JNK (pT183/pY185), p38 (pT180/pY182), p70 S6K (pT412), STAT3 (pS727), STAT5A/B (pY694/699), Akt (pS473)

II. 疾患別での使用例

1.食道がん
HCYTOMAG-60K / Human Cytokine/Chemokine Magnetic Bead Panel

Gastardelo T S, Cunha B R, Raposo L S, et al. Inflammation and cancer: role of annexin A1 and FPR2/ALX in proliferation and metastasis in human laryngeal squamous cell carcinoma
[J]. PloS one, 2014, 9(12): e111317. (PMID: 25490767).
[使用アナライト] IL-6, IL-8, MCP-1

2.乳がん
MCYTOMAG-70K / Mouse Cytokine/Chemokine Magnetic Bead Panel

Sousa S, Auriola S, Mönkkönen J, et al. Liposome encapsulated zoledronate favours M1-like behaviour in murine macrophages cultured with soluble factors from breast cancer cells
[J]. BMC cancer, 2015, 15(1): 4. (PMID: 25588705).
[使用アナライト] IFN-γ, IL-4, IL-10, IL-12(p70), IL-6, M-CSF, MCP-1, TNF-α, VEGF

3.肺がん
48-650MAG / Human Src Family Kinase Active Site Kit

Sutton P, Borgia JA, Bonomi P, et al. Lyn, a Src family kinase, regulates activation of epidermal growth factor receptors in lung adenocarcinoma cells [J]. Mol Cancer. 2013 Jul 16;12:76. (PMID: 23866081) [使用アナライト] Lyn (Tyr397)

4.膀胱がん
APOMAG-62K / Human Apolipoprotein Magnetic Bead Panel

Chen CL, Lin TS, Tsai CH, et al. Identification of potential bladder cancer markers in urine by abundant-protein depletion coupled with quantitative proteomics [J].J Proteomics. 2013 Jun 24;85:28-43. (PMID: 23631828). [使用アナライト] APOA1, APOA2, APOB, APOC2, APOC3, APOE

5.膵臓がん
TGFBMAG-64K-01 / TGFß1 Magnetic Bead Single Plex Kit

Shevchenko I, Karakhanova S, Soltek S, et al. Low-dose gemcitabine depletes regulatory T cells and improves survival in the orthotopic Panc02 model of pancreatic cancer [J].Int J Cancer. 2013 Jul;133(1):98-107. (PMID: 23233419). [使用アナライト] TGF ß1

6.リンパ腫、白血病、自己免疫性リンパ増殖症候群(ALPS)
HCYTMAG-60K-PX38 / Human Cytokine/Chemokine Magnetic Bead Panel - Premixed 38 Plex

Blonska M, Zhu Y, Chuang H, et al. Jun-regulated genes promote interaction of diffuse large B-cell lymphoma with the microenvironment [J]. Blood, 2015, 125(6): 981-991. (PMID: 25533033) [使用アナライト]
sCD40L, EGF, Eotaxin/CCL11, FGF-2, Flt-3 ligand, Fractalkine, G-CSF, GM-CSF, GRO, IFN-α2, IFN-γ, IL-1α, IL-1β, IL-1ra, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12 (p40), IL-12 (p70), IL-13, IL-15, IL-17, IP-10, MCP-1, MCP-3, MDC (CCL22), MIP-1α, MIP-1β, TGF-α, TNF-α, TNF-β, VEGF

46-667MAG / GAPDH Total Magnetic Bead MAPmate,
48-650MAG / Human Src Family Kinase Active Site Kit,
48-680MAG / Multi-Pathway Magnetic Bead 9-Plex

Ariës IM, Jerchel IS, van den Dungen RE, et al. EMP1, a novel poor prognostic factor in pediatric leukemia regulates prednisolone resistance, cell proliferation, migration and adhesion [J]. Leukemia. 2014 Sep;28(9):1828-37. (PMID: 24625531) [使用アナライト]
46-667MAG : GAPDH (total)
48-650MAG : Blk (Tyr389), Fgr (Tyr412), Fyn (Tyr420), Hck (Tyr411), Lck (Tyr394),
Lyn (Tyr397), Src (Tyr419), Yes (Tyr421)
48-680MAG : CREB (pS133), ERK (pT185/pY187), NFκB (pS536), JNK (pT183/pY185), p38 (pT180/pY182), p70 S6K (pT412), STAT3 (pS727), STAT5A/B (pY694/699), Akt (pS473)

48-680MAG / Multi-Pathway Magnetic Bead 9-Plex

Tisato V, Norcio A, Celeghini C, et al. Upregulation of SOCS-1 by Nutlin-3 in acute myeloid leukemia cells but not in primary normal cells [J].Clinics (Sao Paulo). 2014 Jan;69(1):68-74.(PMID: 24473562) [使用アナライト]
CREB (pS133), ERK (pT185/pY187), NFκB (pS536), JNK (pT183/pY185), p38 (pT180/pY182), p70 S6K (pT412), STAT3 (pS727), STAT5A/B (pY694/699), Akt (pS473)

MGAMMAG-300K / Mouse Immunoglobulin Isotyping Magnetic Bead Panel

Guo Q, Zhang J, Li J, Zou L, et al. Forced miR-146a expression causes autoimmune lymphoproliferative syndrome in mice via downregulation of Fas in germinal center B cells [J].Blood. 2013 Jun 13;121(24):4875-83. (PMID: 23645835) [使用アナライト] IgG1, IgG2a, IgG2b, IgG3

7.悪性黒色腫
HCYP2MAG-62K / Human Cytokine/Chemokine Magnetic Bead Panel II

Carreno BM, Becker-Hapak M, Huang A, et al. IL-12p70-producing patient DC vaccine elicits Tc1-polarized immunity [J].J Clin Invest. 2013 Aug;123 (8):3383-94. (PMID: 23867552).

8.卵巣がん
HCCBP1MAG-58K / Human Circulating Cancer Biomarker Magnetic Bead Panel

Pils D, Tong D, Hager G, et al. A combined blood based gene expression and plasma protein abundance signature for diagnosis of epithelial ovarian cancer--a study of the OVCAD consortium [J].BMC Cancer. 2013 Apr 3;13:178. (PMID: 23551967). [使用アナライト] MIF, prolactin, CA125, Leptin, osteopontin, IGF2

9.脳腫瘍
46-667MAG / GAPDH Total Magnetic Bead MAPmate

Dhruv HD, Whitsett TG, Jameson NM, et al. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) promotes glioblastoma cell chemotaxis via Lyn activation
[J]. Carcinogenesis. 2014 Jan;35(1):218-26. (PMID: 23975833).
[使用アナライト] GAPDH(total)

10.多発性硬化症
HCVD2MAG-67K / Human Cardiovascular Disease (CVD) Magnetic Bead Panel 2

Tasset I, Bahamonde C, Agüera E, et al. Effect of natalizumab on oxidative damage biomarkers in relapsing-remitting multiple sclerosis [J].Pharmacol Rep. 2013;65(3):624-31. (PMID: 23950585) [使用アナライト] sVCAM-1, sICAM-1/sICAM

MCD8MAG-48K / Mouse CD8 + T Cell Magnetic Bead Panel

Rainey-Barger EK, Blakely PK, Huber AK, et al. Virus-induced CD8+ T cells accelerate the onset of experimental autoimmune encephalomyelitis: implications for how viral infections might trigger multiple sclerosis exacerbations [J].J Neuroimmunol. 2013 Jun 15;259(1-2):47-54. (PMID: 23602715). [使用アナライト]
CD137, Fas, sFASL, GM-CSF, Granzyme B, IFNγ, IL-2, IL-10, MIP-1β, RANTES, TNF-α

11.糖尿病、肥満
MCYTOMAG-70K / Mouse Cytokine/Chemokine Magnetic Bead Panel

Romero M J, Yao L, Sridhar S, et al. l-Citrulline protects from kidney damage in type 1 diabetic mice [J]. Frontiers in immunology, 2013, 4: 480. (PMID: 24400007). [使用アナライト]
G-CSF, GM-CSF, IFN-γ, IL-1α, IL-1β, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-9, IL-10, IL-12 (p40), IL-12 (p70), IL-13, IL-15, IL-17, IP-10, KC, LIF, LIX, MCP-1, M-CSF, MIG, MIP-1α, MIP-1β, MIP-2, RANTES, TNF-α, VEGF, Eotaxin/CCL11

MCYTMAG-70K-PX32 / Mouse Cytokine/Chemokine Magnetic Bead Panel - Premixed 32 Plex

Awad A S, You H, Gao T, et al. Macrophage-derived tumor necrosis factor-α mediates diabetic renal injury[J]. Kidney international, 2015, 88: 722–733. (PMID: 26061548) [使用アナライト]
G-CSF, GM-CSF, IFN-γ, IL-1α, IL-1β, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-9, IL-10, IL-12 (p40), IL-12 (p70), IL-13, IL-15, IL-17, IP-10, KC, LIF, LIX, MCP-1, M-CSF, MIG, MIP-1α, MIP-1β, MIP-2, RANTES, TNF-α, VEGF, Eotaxin/CCL11

MAGPMAG-24K / Mouse Angiogenesis/Growth Factor Magnetic Bead Panel,
MCYTOMAG-70K / Mouse Cytokine/Chemokine Magnetic Bead Panel

Ezquer F, Giraud-Billoud M, Carpio D, et al. Pro-regenerative microenvironment triggered by donor mesenchymal stem cells preserves renal function and structure in mice with severe [J].Diabetes Mellitus BioMed Research International 2015, Article ID 164703, 23 pages. (PMID: 26167475). [使用アナライト]
MAGPMAG-24K : EGF, ET1/Endothelin 1, b-FGF, HGF, VEGF MCYTOMAG-70K : IL-1β, IL-6, IL-10, IL-13, TNF-α

APOMAG-62K / Human Apolipoprotein Magnetic Bead Panel

Stringer DM, Taylor CG, Appah P, et al. Consumption of buckwheat modulates the post-prandial response of selected gastrointestinal satiety hormones in individuals with type 2 diabetes mellitus [J].Metabolism. 2013 Jul;62(7):1021-31.(PMID: 23485142). [使用アナライト] Apo A I, Apo B, Apo C III

HADCYMAG-61K / Human Adipocyte Magnetic Bead Panel

Codoñer-Franch P, Tavárez-Alonso S, Porcar-Almela M, et al. Plasma resistin levels are associated with homocysteine, endothelial activation, and nitrosative stress in obese youths[J].Clin Biochem. 2014 Jan;47(1-2):44-8. (PMID: 24183883). [使用アナライト] Adiponectin, Leptin, Resistin

HADK2MAG-61K / Human Adipokine Magnetic Bead Panel 2

Sijtsma A, Bocca G, L'abée C, et al. Waist-to-height ratio, waist circumference and BMI as indicators of percentage fat mass and cardiometabolic risk factors in children aged 3-7 years.[J].Clin Nutr. 2014 Apr;33(2):311-5. (PMID: 23768783). [使用アナライト] IL-6, TNFα

HCCBP1MAG-58K / Human Circulating Cancer Biomarker Magnetic Bead Panel

Loria-Kohen V, Fernández-Fernández C, Bermejo LM, et al. Effect of different exercise modalities plus a hypocaloric diet on inflammation markers in overweight patients: a randomised trial.[J].Clin Nutr. 2013 Aug;32(4):511-8. (PMID: 23177481). [使用アナライト] Leptin, IL-6, TNF-α

MADKMAG-71K / Mouse Adipokine Magnetic Bead Panel

Mackay H, Patterson ZR, Khazall R, et al. Organizational effects of perinatal exposure to bisphenol-A and diethylstilbestrol on arcuate nucleus circuitry controlling food intake and energy expenditure in male and female CD-1 mice.[J].Endocrinology. 2013 Apr;154 (4):1465-75. (PMID: 23493373) [使用アナライト] IL-6, insulin, Leptin, Resistin

MADKMAG-71K / Mouse Adipokine Magnetic Bead Panel,
MADPNMAG-70K-01 / Mouse Adiponectin Magnetic Bead Single Plex Kit

Wahlang B1, Falkner KC, Gregory B, et al. Polychlorinated biphenyl 153 is a diet-dependent obesogen that worsens nonalcoholic fatty liver disease in male C57BL6/J mice [J]. J Nutr Biochem. 2013 Sep;24(9):1587-95. (PMID: 23618531). [使用アナライト]
MADKMAG-71K : Leptin
MMADPNMAG-70K-01 : Adiponectin

NHPMHMAG-45K / Non-Human Primate Metabolic Magnetic Bead Panel

Frantz ED, Crespo-Mascarenhas C, Barreto-Vianna AR, et al. Renin-angiotensin system blockers protect pancreatic islets against diet-induced obesity and insulin resistance in mice [J].PLoS One. 2013 Jul 22;8(7):e67192. (PMID: 23894285). [使用アナライト] Insulin, Glucagon

12.免疫グロブリン サブタイプ解析
HGAMMAG-301K / Human Isotyping Magnetic Bead Panel

Andersen N J, Mondal T K, Preissler M T, et al. Detection of immunoglobulin isotypes from dried blood spots [J]. Journal of immunological methods, 2014, 404: 24-32. (PMID: 24333851) [使用アナライト] IgM, IgA

13.認知障害、精神疾患
RSHMAG-69K / Rat Stress Hormone Magnetic Bead Panel

Justice N J, Huang L, Tian J B, et al. Posttraumatic Stress Disorder-Like Induction Elevates β-Amyloid Levels, Which Directly Activates Corticotropin-Releasing Factor Neurons to Exacerbate Stress Responses[J]. The Journal of Neuroscience, 2015, 35(6): 2612-2623. (PMID: 25673853) [使用アナライト] Corticosteroid/Corticosterone

MBNMAG-41K / Mouse Bone Magnetic Bead Panel

Pang TY, Du X, Catchlove WA, et al. Positive environmental modification of depressive phenotype and abnormal hypothalamic-pituitary-adrenal axis activity in female C57BL/6J mice during abstinence from chronic ethanol consumption [J]. Front Pharmacol. 2013 Jul 23;4:93. (PMID: 23898297). [使用アナライト] ACTH

NHPPT1MG-46K / Non-Human Primate Pituitary Magnetic Bead Panel 1

Camus SM, Blois-Heulin C, Li Q, et al. Behavioural profiles in captive-bred cynomolgus macaques: towards monkey models of mental disorders? [J]. PLoS One. 2013 Apr 29;8(4):e62141. (PMID: 23658620) [使用アナライト] ACTH

14.嚢胞性繊維症
HMMP2MAG-55K / Human MMP Magnetic Bead Panel 2
HTMP1MAG-54K / Human TIMP Magnetic Bead Panel 1

U Müller, J Hentschel, WK Janhsen , et al. Changes of Proteases, Antiproteases, and Pathogens in Cystic Fibrosis Patients’ Upper and Lower Airways after IV-Antibiotic Therapy
[J]. Mediators of Inflammation, Volume 2015 (2015), Article ID 626530, 16 pages. (PMID: 26185365)
[使用アナライト]
HMMP2MAG-55K : MMP-9
HTMP1MAG-54K : TIMP-1

15.心疾患
HADK1MAG-61K / Human Adipokine Magnetic Bead Panel 1

Schopfer DW, Ku IA, Regan M, et al. Growth differentiation factor 15 and cardiovascular events in patients with stable ischemic heart disease (The Heart and Soul Study) [J]. Am Heart J. 2014 Feb;167(2):186-192.e1.(PMID: 24439979). [使用アナライト] Adiponectin, Resistin

HCYP2MAG-62K / Human Cytokine/Chemokine Magnetic Bead Panel II

Mansell H, Rosaasen N, Dean J, et al. Evidence of enhanced systemic inflammation in stable kidney transplant recipients with low Framingham risk scores [J]. Clin Transplant. 2013 Jul-Aug;27(4):E391-9. (PMID: 23782452). [使用アナライト]
6Ckine/CCL21, CTACK/CCL27, Eotaxin-2/CCL24, Eotaxin-3/CCL26, I-309/CCL1,
MCP-2/CCL8, MCP-4/CCL13, MIP-1δ/CCL15, TARC/CCL17

TGFBMAG-64K-01 / TGFß1 Magnetic Bead Single Plex Kit

Zhang H, Zhong H, Everett TH 4th, et al. Blockade of A2B adenosine receptor reduces left ventricular dysfunction and ventricular arrhythmias 1 week after myocardial infarction in the rat model [J]. Heart Rhythm. 2014 Jan;11(1):101-9. (PMID: 24120874). [使用アナライト] TGF ß1

16.腎臓病
HADK1MAG-61K / Human Adipokine Magnetic Bead Panel 1

Hung AM, Sundell MB, Plotnikova NE, et al. A pilot study of active vitamin D administration and insulin resistance in African American patients undergoing chronic hemodialysis
[J]. J Ren Nutr. 2013 May;23(3):185-93. (PMID: 22959781).
[使用アナライト] Adiponectin, Resistin

HADK2MAG-61K / Human Adipokine Magnetic Bead Panel 2

Garland JS, Holden RM, Ross R, et al. Insulin resistance is associated with Fibroblast Growth Factor-23 in stage 3-5 chronic kidney disease patients [J]. J Diabetes Complications. 2014 Jan-Feb;28(1):61-5. (PMID: 24125760). [使用アナライト] Insulin

MGAMMAG-300K / Mouse Immunoglobulin Isotyping Magnetic Bead Panel

Lee SW, Park KH, Park S, et al. Soluble receptor for advanced glycation end products alleviates nephritis in (NZB/NZW)F1 mice [J]. Arthritis Rheum. 2013 Jul;65(7):1902-12. (PMID: 23553192). [使用アナライト IgG1, IgG2a, IgG2b, IgG3

17.毒性(心毒性)
HTMP2MAG-54K / Human TIMP Magnetic Bead Panel 2

Herrmann JE, Heale J, Bieraugel M, et al. Isoproterenol effects evaluated in heart slices of human and rat in comparison to rat heart in vivo [J]. Toxicol Appl Pharmacol. 2014 Jan 15;274(2):302-12. (PMID: 24286936). [使用アナライト] TIMP-1, TIMP-2, TIMP-3, TIMP-4

18.乾癬
HCVD2MAG-67K / Human Cardiovascular Disease (CVD) Magnetic Bead Panel 2

Sigurdardottir G, Ekman AK, Ståhle M, et al. Systemic treatment and narrowband ultraviolet B differentially affect cardiovascular risk markers in psoriasis [J]. J Am Acad Dermatol. 2014 Jun;70(6):1067-75. (PMID: 24656729). [使用アナライト] sVCAM-1, sICAM-1, sE-selectin/sP-Selectin, MPO

19.睡眠時無呼吸症候群
HIGFMAG-52K / Human IGF-I, II Magnetic Bead Panel

Fung AM, Wilson DL, Lappas M, et al. Effects of maternal obstructive sleep apnoea on fetal growth: a prospective cohort study [J]. PLoS One. 2013 Jul 24;8(7):e68057. (PMID: 23894293). [使用アナライト] IGF-1, IGF-2

20.疼痛
HNPMAG-35K / Human Neuropeptide Magnetic Bead Panel

Molina-Ortega F, Lomas-Vega R, Hita-Contreras F, et al. Immediate effects of spinal manipulation on nitric oxide, substance P and pain perception [J]. Man Ther. 2014 Oct;19(5):411-7. (PMID: 24674816). [使用アナライト] Substance P

21.黄熱病
HCVD3MAG-67K / Human Cardiovascular Disease (Acute Phase) Magnetic Bead Panel 3

Woodson SE, Freiberg AN, Holbrook MR. Coagulation factors, fibrinogen and plasminogen activator inhibitor-1, are differentially regulated by yellow fever virus infection of hepatocytes [J].Virus Res. 2013 Aug;175(2):155-9. (PMID: 23639427). [使用アナライト] Fibrinogen

22.生殖・精子形成
MPTMAG-49K / Mouse Pituitary Magnetic Bead Panel

Pitetti JL, Calvel P, Zimmermann C, et al. An essential role for insulin and IGF1 receptors in regulating sertoli cell proliferation, testis size, and FSH action in mice [J]. Mol Endocrinol. 2013 May;27(5):814-27. (PMID: 23518924). [使用アナライト] FSH, LH

III. 特殊サンプルでの使用例

1.組織ライセート
下垂体腺
RPTMAG-86K / Rat Pituitary Magnetic Bead Panel

Roper L K, Briguglio J S, Evans C S, et al. Sex-specific regulation of follicle-stimulating hormone secretion by synaptotagmin 9 [J]. Nature communications, 2015, 6. doi:10.1038/ncomms9645. (PMID: 26482442). [使用アナライト] FSH, LH, GH

腎臓
PCYTMAG-23K / Porcine Cytokine/Chemokine Magnetic Bead Panel

Gardner D S, De Brot S, Dunford L J, et al. Remote conditioning or erythropoietin before surgery primes kidneys to clear ischemia-reperfusion-damaged cells: a renoprotective mechanism? [J]. Am J Physiol Renal Physiol. 2014 Apr 15; 306(8): F873–F884. (PMID: 24523383). [使用アナライト] IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-10, IL-12, IL-18, TNF-α

2.末梢血単核細胞
HTH17MAG-14K / Human TH17 Magnetic Bead Panel
HGAMMAG-301K / Human Isotyping Magnetic Bead Panel

Boswell K L, Paris R, Boritz E, et al. Loss of circulating CD4 T cells with B cell helper function during chronic HIV infection [J]. PLoS pathogens, 2014, 10(1). (PMID: 24497824). [使用アナライト]
HTH17MAG-14K : IFN-γ, IL-2, IL-4, IL-6, IL-10, IL-17, IL-21, TNF-α
HGAMMAG-301K : IgG1, IgG2, IgG3, IgG4, IgA, IgM

3.鼻洗浄液, 唾液
HMMP2MAG-55K / Human MMP Magnetic Bead Panel 2
HTMP1MAG-54K / Human TIMP Magnetic Bead Panel 1

U Müller, J Hentschel, WK Janhsen , et al. Changes of Proteases, Antiproteases, and Pathogens in Cystic Fibrosis Patients’ Upper and Lower Airways after IV-Antibiotic Therapy [J]. Mediators of Inflammation, Volume 2015 (2015), Article ID 626530, 16 pages. (PMID: 26185365). [使用アナライト]
HMMP2MAG-55K : MMP-9
HTMP1MAG-54K : TIMP-1

 
Tips

ライフサイエンス Tips・
アプリケーション・事例

製品や技術のTipsや最新アプリケーション、ケーススタディを掲載
学術情報

ライフサイエンス学術情報・
刊行物

最新の技術情報誌や学術資料を掲載