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14-249M p38δ/SAPK4 Protein, active, 250 µg

Active, recombinant GST fusion protein fused to full length human p38δ/SAPK4, for use in Kinase Assays.

p38δ/SAPK4 Protein, active, 250 µg MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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14-249M
250 µg  Also available in 10 μg size (cat#14-249) and in bulk (cat# 14-249-K).
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      Overview

      Replacement Information
      Description
      Catalogue Number14-249M
      Brand Family Upstate
      Trade Name
      • Upstate
      Descriptionp38δ/SAPK4 Protein, active, 250 µg
      OverviewRecombinant GST fusion protein fused to full length human p38δ/SAPK4

      CHK3
      References
      Product Information
      Quality LevelMQ100
      Applications
      ApplicationActive, recombinant GST fusion protein fused to full length human p38δ/SAPK4, for use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      Sourceexpressed in E. coli
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and cellular stress. MAP kinase kinases 3, and 6 can phosphorylate and activate this kinase. Transcription factor ATF2, and microtubule dynamics regulator stathmin have been shown to be the substrates of this kinase.
      Gene Symbol
      • MAPK13
      • MGC99536
      • PRKM13
      • SAPK4
      • p38delta
      Protein Targetp38δ/SAPK4
      Purification MethodAffinity chromatography on glutathione Sepharose™ beads after activation with SKK3/MEK6
      Target Sub-FamilyCMGC
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: O15264 # Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating downstream targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K.
      COFACTOR: Magnesium.
      SIZE: 365 amino acids; 42090 Da
      TISSUE SPECIFICITY: Expressed in testes, pancreas, small intestine, lung and kidney. Abundant in macrophages, also present in neutrophils, CD4+ T-cells, and endothelial cells.
      DOMAIN: SwissProt: O15264 The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
      PTM: Dually phosphorylated on Thr-180 and Tyr-182, which activates the enzyme.
      SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. & Contains 1 protein kinase domain.
      Molecular Weight71kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by phosphorylation of MBP in vitro
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -20°C
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10 μg size (cat#14-249) and in bulk (cat# 14-249-K).
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      14-249M 04053252731075

      Related Products & Applications

      Alternative Packsize

      Catalogue Number Description  
      14-249 p38δ/SAPK4 Protein, active, 10 µg Show Pricing & Availability

      Product Families

      Kinase & Phosphatase Products

      Millipore offers a large portfolio of Kinases, Phophatases, Substrates, Inhibitors, Kits, reagents & tools for Signaling research. See below for a list of these products, in multiple pack sizes.
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      Categories

      Life Science Research > Proteins and Enzymes > Purified Kinases
      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases