BioTracker Tau filaments pFTAA Live Cell Dye

Purity: ≥98% confirmed by HNMR, LC-MS and HPLC and elemental analysis

Molar Mass: 704.65 g/mol

Application: Live cell fluorescent imaging

Live cell imaging dye for detection of disease-associated protein aggregates such as Amyloid protein deposits.

Protein misfolding diseases are characterized by deposition of protein aggregates. Accumulation of protein deposits, so-called amyloid, is the histopathological hallmark of several devastating diseases, and the development of sensitive optical ligands to detect and characterize these disease-associated structures is of great interest.

The BioTracker Tau filaments pFTAA live cell dye is a novel fluorescent probe that can bind to and discriminate between amyloid-b (A?) plaques and tau neurofibrillary tangles (NFTs) in Alzheimer′s disease (AD)-like pathology in transgenic mouse brain tissue sections.

Spectral Properties:

• Excitation: 405 nm
• Emissions: 550 nm

References:
Klingstedt T et al. The Structural Basis for Optimal Performance of Oligothiophene-Based Fluorescent Amyloid Ligands: Conformational Flexibility is Essential for Spectral Assignment of a Diversity of Protein Aggregates. Chem Eur J. 2013, 19, 10179-10192.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial