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Merck

1.08219

Tris(hydroxymethyl)aminomethane hydrochloride

EMPROVE® EXPERT

Synonym(s):

Trizma® hydrochloride, TRIS HCl, TRIS hydrochloride, Tris(hydroxymethyl)aminomethane hydrochloride, Tromethane hydrochloride

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About This Item

Linear Formula:
NH2C(CH2OH)3 · HCl
CAS Number:
1185-53-1
Molecular Weight:
157.60
EC Index Number:
214-684-5
UNSPSC Code:
12352107
Beilstein/REAXYS Number:
3675235
MDL number:
MFCD00012590

Key Documents

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Product Name

Tris(hydroxymethyl)aminomethane hydrochloride, EMPROVE® EXPERT

SMILES string

Cl.NC(CO)(CO)CO

InChI key

QKNYBSVHEMOAJP-UHFFFAOYSA-N

InChI

1S/C4H11NO3.ClH/c5-4(1-6,2-7)3-8;/h6-8H,1-3,5H2;1H

vapor pressure

<1 Pa ( 50 °C)

product line

EMPROVE® EXPERT

form

solid

feature

RNase and DNase free

Quality Level

500

technique(s)

in vitro transcription (IVT): suitable

pH

4.2 (20 °C, 100 g/L in H2O)

useful pH range

7.0-9.0

pKa (25 °C)

8.1

mp

150.7 °C

solubility

soluble 561 g/L

density

1.28 g/cm3 at 20.2 °C

application(s)

parenterals

storage temp.

15-25°C

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General description

Finding the right chemical that matches your pharma and biopharma manufacturing needs as well as regulatory demands can be a complicated challenge. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for pharma and biopharma manufacturing withstands strict quality control procedures and is produced according to applicable cGMP guidelines.
Our SAFC® portfolio of high-quality products for biopharmaceutical processing withstands strict quality control procedures and is produced according to MQ-500 requirements as defined by the M-Clarity program.

M-Clarity Program

As part of our EMPROVE® Program, our raw materials are offered with EMPROVE® Dossiers which provide comprehensive, up-to-date documentation to help you navigate regulatory challenges, manage risks, and improve your manufacturing processes.

Buffer quality is vital for the success of biopharmaceutical processes, because buffers are indispensable in nearly every production step.

Our broad portfolio of buffer materials manufactured under appropriate controls is tailored to your needs. Ranging from non-GMP grades for low-risk application, to IPEC-PQG GMP for higher-risk applications, we have products covering all your manufacturing needs.

Other Notes

Due to its low microbial and endotoxin limits, Tris(hydroxymethyl)aminomethane hydrochloride Emprove® Expert is suitable for biopharma manufacturing needs.
The pH values of all buffers are temperature and concentration dependent. For Tris buffers, pH increases about 0.03 unit per °C decrease in temperature, and decreases 0.03-0.05 unit per ten-fold dilution. For precise applications, use a carefully calibrated pH meter with a glass/calomel combination electrode.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany
Trizma is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

1082199999: + 1082190750: + 1082190050: + 1082199250: + 1082199010: + 1082191000: + 1082190003: + 1082199011: + 1082191003: + 1082199012: + 1082195000: + 1082199053: + CO1E1082199010: + 1082190000: + 1082199050: + 1082197777: + 1082199013: + 1082199336:

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Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Global Trade Item Number

SKUGTIN
1.08219.901004022536702742
1.08219.500004022536532899
1.08219.100004022536101811

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