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676492 VEGFR3 Kinase Inhibitor, MAZ51 - CAS 163655-37-6 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
163655-37-6C₂₁H₁₈N₂O

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676492-10MGCN
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      Description
      OverviewA cell-permeable 3-substituted indolin-2-one compound that acts as a reversible and ATP-competitive VEGF receptor tyrosine kinase inhibitor. At low concentration (≤5 µM), it specifically blocks VEGF-C- (Cat. No. 676476) and VEGF-D- (Cat. No. 676471) induced phosphorylation of VEGFR-3, but not VEGFR-2, in PAE cells. It partially blocks VEGFR-2 phosphorylation only at higher concentrations (50 µM). This differential blocker may be useful for inhibiting lymphangiogenesis-dependent pathological process such as tumor metastasis. Not available for sale in Germany.
      Catalogue Number676492
      Brand Family Calbiochem®
      SynonymsMAZ51, 3-(4-Dimethylamino-naphthalen-1-ylmethylene)-1,3-dihydro-indol-2-one, Vascular Endothelial Growth Factor Receptor 3 Kinase Inhibitor, VEGFR Tyrosine Kinase Inhibitor XVI, VEGFR3 Kinase Inhibitor I
      References
      ReferencesKirkin, V., et al. 2001. Eur. J. Biochem. 268, 5530
      Product Information
      CAS number163655-37-6
      ATP CompetitiveY
      DeclarationNot available for sale in Germany.
      FormRed solid
      Hill FormulaC₂₁H₁₈N₂O
      Chemical formulaC₂₁H₁₈N₂O
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationVEGFR3 Kinase Inhibitor, MAZ51, CAS 163655-37-6, is a cell-permeable, reversible, ATP-competitive inhibitor of VEGF receptor tyrosine kinase. Blocks VEGF-C & VEGF-D-induced phosphorylation of VEGFR-3.
      Biological Information
      Primary TargetVEGF receptor tyrosine kinase
      Primary Target IC<sub>50</sub>At low concentration (≤5 µM), it specifically blocks VEGF-C- and VEGF-D-induced phosphorylation of VEGFR-3, but not VEGFR-2, in PAE cells.
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      676492-10MGCN 04055977183689