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SCC074 UM-SCC-17A Squamous Carcinoma Cell Line

UM-SCC-17A is a unique head and neck squamous carcinoma cell line isolated from the primary laryngeal carcinoma of a 48-year old female patient who failed to respond to radiation therapy and is a suitable in vitro model of H&N carcinoma studies.

UM-SCC-17A Squamous Carcinoma Cell Line MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Key Applications: Cell Culture
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SCC074
≥1X10⁶ cells/vial  
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      Overview

      Replacement Information

      Key Spec Table

      Key Applications
      CULT
      Description
      Catalogue NumberSCC074
      DescriptionUM-SCC-17A Squamous Carcinoma Cell Line
      OverviewAll UM-SCC cell lines were derived in the lab of Dr. Thomas Carey at the University of Michigan and are exclusively distributed by Merck KGaA. Access to UM-SCC cells is limited solely to those officers, employees and students of PURCHASER’s institution who need access to perform research. PURCHASER may not distribute UM-SCC cells or derivatives to third parties. PURCHASER shall comply with all applicable laws in its use and handling of the Product and shall keep it under reasonable safe and secure conditions to prevent unauthorized use or access.

      THIS PRODUCT IS ONLY AVAILABLE FOR SALE TO ACADEMIC INSTITUTIONS OR NOT-FOR-PROFIT ENTITIES FOR USE UNDER THIS LIMITED USE LABEL LICENSE. FOR INFORMATION ON COMMERCIAL LICENSING OF UM-SCC CELLS, INCLUDING LICENSING TO COMMERCIAL ENTITIES, PLEASE CONTACT: licensing@emdmillipore.com
      Alternate Names
      • UMSCC17A
        HNSCC
        Head and neck squamous cell carcinoma cell line
        H&N squamous cell carcinoma cell line
      Background InformationUM-SCC-17A is a unique head and neck squamous carcinoma cell line isolated from the primary laryngeal carcinoma of a 48-year old female patient who failed to respond to radiation therapy. The tumor persisted and metastasized to the neck, from where the UM-SCC-17B cell line was derived from. The patient achieved long-term remission after surgery (1, 2). UM-SCC-17A is negative for HPV-16, HPV-18, Hepatitis A, B, C, HIV-1 & 2 viruses and grows as tightly packed colonies or islands.

      UM-SCC-17A was established at the University of Michigan with written informed consent obtained from the patient and with the approval of the study by the Medical School Institutional Review Board.

      References:
      1. Carey, T.E., Van Dyke, D.L., Worsham, M.J., Bradford, C.R., Babu, V.R., Schwartz, D.R., Hsu, S., Baker, S.R. (1989) Characterization of human laryngeal primary and metastatic squamous cell carcinoma cell lines UM-SCC-17A and UM-SCC-17B. Cancer Res 49(21): 6098-6107.
      2. Brenner, J.C., Graham, M.P., Kumar, B., Saunders, L.M., Kupfer, R., Lyons, R.H., Bradford, C.R., Carey, T.E. (2010) Genotyping of 73 UM-SCC head and neck squamous cell carcinoma cell lines. Head Neck 32(4):417-426.
      References
      Product Information
      Quality LevelMQ100
      Applications
      ApplicationUM-SCC-17A is a unique head and neck squamous carcinoma cell line isolated from the primary laryngeal carcinoma of a 48-year old female patient who failed to respond to radiation therapy and is a suitable in vitro model of H&N carcinoma studies.
      Key Applications
      • Cell Culture
      Application NotesThis product is available for sale to academic institutions or not-for-profit entities for research use. For information on commercial licensing please contact licensing@emdmillipore.com.
      Biological Information
      ConcentrationPlease refer to lot specific datasheet.
      Cell Line Type
      • Endothelial Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assurance• Each vial contains ≥ 1X106 viable cells.
      • Cells are tested by PCR and are negative for HPV-16, HPV-18, Hepatitis A, B, C and HIV-1 & 2 viruses.
      • Cells are negative for mycoplasma contamination.
      • Each lot of cells are genotyped by STR analysis to verify the unique identity of the cell line.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsUM-SCC-17A cells should be stored in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
      Packaging Information
      Material Size≥1X10⁶ cells/vial
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      SCC074 04054839049095