Millipore Sigma Vibrant Logo

612200 Tissue Plasminogen Activator, Human

Tissue Plasminogen Activator, Human MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: tPA

View This Product on Sigma-Aldrich
612200
View Pricing & Availability

Overview

Replacement Information

Pricing & Availability

Catalogue Number AvailabilityPackaging Qty/Pack Price Quantity
612200-100UGCN
Retrieving availability...
—
Limited Availability Limited Availability
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      		 Plastic ampoule 100 μg
      Retrieving price...
      Price could not be retrieved
      Minimum Quantity is a multiple of
      Maximum Quantity is
      Upon Order Completion More Information
      You Saved ()
       
      —
      Request Pricing
      		 —
      612200-1MGCN
      Retrieving availability...
      —
      Limited Availability Limited Availability
      In Stock 
      Discontinued
      Limited Quantities Available
      Availability to be confirmed
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service
          Contact Customer Service

          		 Glass bottle 1 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity is a multiple of
          Maximum Quantity is
          Upon Order Completion More Information
          You Saved ()
           
          —
          Request Pricing
          		 —
          Description
          OverviewNative tissue plasminogen activator from a human melanoma cell line. A serine protease that contains a single chain of 527 amino acids. Binds to fibrin via lysine binding sites at its amino terminus and activates bound plasminogen. Cleaves plasminogen to form active plasmin, the proteolytic enzyme that dissolves clots. Reported to be involved in neurite outgrowth, regeneration, and migration. Plays an important role in excitotoxin-induced neuronal degeneration.
          Catalogue Number612200
          Brand Family Calbiochem®
          SynonymstPA
          References
          ReferencesKim, Y.H., et al. 1999. Science 284, 647.
          Tsirka, S.E., et al. 1995. Nature 377, 340.
          Winther, K., et al. 1992. J. Cardiovasc. Pharmacol. 19, S21.
          Product Information
          FormLyophilized
          FormulationLyophilized from 100 mM PBS, 3.5 mg/ml L-arginine, 0.001% Tween®-80 Detergent.
          Quality LevelMQ100
          Applications
          Biological Information
          Purity≥95% by SDS-PAGE
          SourcePrepared from cell line that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
          Specific Activity≥300 KU/mg protein
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Catalogue Number GTIN
          612200-100UGCN 04055977187762
          612200-1MGCN 04055977187755

          Documentation

          Tissue Plasminogen Activator, Human SDS

          Title

          Safety Data Sheet (SDS) 

          Tissue Plasminogen Activator, Human Certificates of Analysis

          TitleLot Number
          612200

          References

          Reference overview
          Kim, Y.H., et al. 1999. Science 284, 647.
          Tsirka, S.E., et al. 1995. Nature 377, 340.
          Winther, K., et al. 1992. J. Cardiovasc. Pharmacol. 19, S21.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision17-May-2011 JSW
          SynonymstPA
          DescriptionNative tissue plasminogen activator from a human melanoma cell line. A serine protease that contains a single chain of 527 amino acid residues. Binds to fibrin via lysine binding sites at its amino terminus and activates bound plasminogen. Cleaves plasminogen to form active plasmin, the proteolytic enzyme that dissolves clots. Reported to be involved in neurite outgrowth, regeneration, and migration. Plays an important role in excitotoxin-induced neuronal degeneration. Dihydropyridine Ca2+ antagonist may increase levels of tPA.
          FormLyophilized
          FormulationLyophilized from 100 mM PBS, 3.5 mg/ml L-arginine, 0.001% Tween®-80 Detergent.
          SourcePrepared from cell line that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
          Purity≥95% by SDS-PAGE
          Specific activity≥300 KU/mg protein
          SolubilityReconstitute with diH₂O to a final concentration of 1 mg/ml (e.g., 100 µg should be reconstituted in 100 µl).
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesKim, Y.H., et al. 1999. Science 284, 647.
          Tsirka, S.E., et al. 1995. Nature 377, 340.
          Winther, K., et al. 1992. J. Cardiovasc. Pharmacol. 19, S21.