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05-23-0600 Substance P - CAS 33507-63-0 - Calbiochem

Neuropeptide found in high concentrations in the gut.

Substance P - CAS 33507-63-0 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: RPKPQQFFGLM

Primary Target: Substance P receptors
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05-23-0600
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
33507-63-0C₆₃H₉₈N₁₈O₁₃S

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          05-23-0600-5MGCN
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              Description
              OverviewNeuropeptide found in high concentrations in the gut. When released from afferent nerves, causes a neurogenic inflammatory response, including mast cell degranulation. Induces Ca2+ mobilization. Reported to activate Goα, Gq/11α, and Gsα subunits in CHO cells via activation of substance P receptors. Also reported to induce superoxide production in neutrophils.
              Catalogue Number05-23-0600
              Brand Family Calbiochem®
              SynonymsRPKPQQFFGLM
              References
              ReferencesRoush, E.D., and Kwatra, M.M. 1998. FEBS Lett. 428, 291.
              Chiwakata, C.B., et al. 1996. Infect. Immun. 64, 5106.
              Tanabe, T., et al. 1996. Eur. J. Pharmacol. 299, 187.
              Heath, M.J., et al. 1994. J. Neurophysiol. 72, 1192.
              Zhu, J., et al. 1994. Eur. J. Pharmacol. 268, 279.
              Garland, A.M., et al. 1993. Soc. Neurosci. 19, Abstract 104.6.
              Wei, J.Y., et al. 1993. Soc. Neurosci. 19, Abstract 136.14.
              Product Information
              CAS number33507-63-0
              ATP CompetitiveN
              FormWhite solid
              FormulationSupplied as a trifluoroacetate salt.
              Hill FormulaC₆₃H₉₈N₁₈O₁₃S
              Chemical formulaC₆₃H₉₈N₁₈O₁₃S
              Hygroscopic Hygroscopic
              ReversibleN
              Sold on the basis of peptide contentY
              Quality LevelMQ100
              Applications
              Biological Information
              Primary TargetSubstance P receptors
              Purity≥96% by HPLC
              Physicochemical Information
              Cell permeableN
              Peptide ContentY
              Peptide SequenceH-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH₂
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage -20°C
              Hygroscopic Hygroscopic
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications
              Global Trade Item Number
              Catalogue Number GTIN
              05-23-0600-1MGCN 04055977207019
              05-23-0600-25MGCN 04055977207026
              05-23-0600-5MGCN 04055977207033

              Documentation

              Substance P - CAS 33507-63-0 - Calbiochem SDS

              Title

              Safety Data Sheet (SDS) 

              Substance P - CAS 33507-63-0 - Calbiochem Certificates of Analysis

              TitleLot Number
              05-23-0600

              References

              Reference overview
              Roush, E.D., and Kwatra, M.M. 1998. FEBS Lett. 428, 291.
              Chiwakata, C.B., et al. 1996. Infect. Immun. 64, 5106.
              Tanabe, T., et al. 1996. Eur. J. Pharmacol. 299, 187.
              Heath, M.J., et al. 1994. J. Neurophysiol. 72, 1192.
              Zhu, J., et al. 1994. Eur. J. Pharmacol. 268, 279.
              Garland, A.M., et al. 1993. Soc. Neurosci. 19, Abstract 104.6.
              Wei, J.Y., et al. 1993. Soc. Neurosci. 19, Abstract 136.14.
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision02-February-2023 JSW
              SynonymsRPKPQQFFGLM
              DescriptionNeuropeptide found in high concentrations in the gut. When released from afferent nerves, causes a neurogenic inflammatory response, including mast cell degranulation. Induces Ca2+ mobilization. Reported to activate Goα, Gq/11α, and Gsα subunits in CHO cells via activation of substance P receptors. Also reported to induce superoxide production in neutrophils.
              FormWhite solid
              FormulationSupplied as a trifluoroacetate salt.
              CAS number33507-63-0
              Chemical formulaC₆₃H₉₈N₁₈O₁₃S
              Peptide SequenceH-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH₂
              Purity≥96% by HPLC
              Solubility5% Acetic Acid (1 mg/ml)
              Storage -20°C
              Hygroscopic
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Toxicity Standard Handling
              Merck USA index14, 8863
              ReferencesRoush, E.D., and Kwatra, M.M. 1998. FEBS Lett. 428, 291.
              Chiwakata, C.B., et al. 1996. Infect. Immun. 64, 5106.
              Tanabe, T., et al. 1996. Eur. J. Pharmacol. 299, 187.
              Heath, M.J., et al. 1994. J. Neurophysiol. 72, 1192.
              Zhu, J., et al. 1994. Eur. J. Pharmacol. 268, 279.
              Garland, A.M., et al. 1993. Soc. Neurosci. 19, Abstract 104.6.
              Wei, J.Y., et al. 1993. Soc. Neurosci. 19, Abstract 136.14.