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567020 Simvastatin - CAS 79902-63-9 - Calbiochem

A lipophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks Ras function through inhibition of farnesylation.

Simvastatin - CAS 79902-63-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: MK-733, L-Type Calcium Channel Blocker VI

Primary Target: farnesylation
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567020
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
79902-63-9C₂₅H₃₈O₅

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567020-50MGCN
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      Description
      OverviewA lipophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks Ras function through inhibition of farnesylation. Also inhibits glucose-induced Ca2+ signaling and insulin secretion by blocking L-type Ca2+ channels in rat islet β-cells. Inhibits cell proliferation of human smooth muscle cells. Note: this product is supplied in an inactive form and requires treatment with NaOH in EtOH followed by neutralization to pH 7.2 for activation.
      Catalogue Number567020
      Brand Family Calbiochem®
      SynonymsMK-733, L-Type Calcium Channel Blocker VI
      References
      ReferencesYada, T., et al. 1999. Br. J. Pharmacol. 126, 1205.
      Clutterbuck, R.D., et al. 1998. Br. J. Haematol. 102, 522.
      Yokoyama, K., et al. 1998. Mol. Biochem. Parasitol. 94, 87.
      Negre-Aminou, P., et al. 1997. Biochim. Biophys. Acta 1345, 259.
      Vrtovsnik, F., et al. 1997. Kidney Int. 52, 1016.
      Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.
      Product Information
      CAS number79902-63-9
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₂₅H₃₈O₅
      Chemical formulaC₂₅H₃₈O₅
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetfarnesylation
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      ContaminantsHeavy metals: <20 ppm
      Heavy metals≤20 ppm
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSEK7798000
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution in ethanol-NaOH, aliquot and freeze (-20°C) Ethanol-NaOH solutions are stable for up to 1 month at -20°C. Neutralized solutions should be used immediately.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      567020-50MGCN 04055977267099

      Documentation

      Simvastatin - CAS 79902-63-9 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Simvastatin - CAS 79902-63-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      567020

      References

      Reference overview
      Yada, T., et al. 1999. Br. J. Pharmacol. 126, 1205.
      Clutterbuck, R.D., et al. 1998. Br. J. Haematol. 102, 522.
      Yokoyama, K., et al. 1998. Mol. Biochem. Parasitol. 94, 87.
      Negre-Aminou, P., et al. 1997. Biochim. Biophys. Acta 1345, 259.
      Vrtovsnik, F., et al. 1997. Kidney Int. 52, 1016.
      Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-May-2008 RFH
      SynonymsMK-733, L-Type Calcium Channel Blocker VI
      DescriptionA lipophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks Ras function through inhibition of farnesylation. Also inhibits glucose-induced Ca2+-signaling and insulin secretion by blocking L-type Ca2+ channels in rat islet β-cells. Inhibits cell proliferation of human smooth muscle cells. Note: This product is supplied in an inactive form and requires treatment with NaOH in ethanol followed by neutralization to pH 7.2 for activation.
      FormOff-white solid
      CAS number79902-63-9
      RTECSEK7798000
      Chemical formulaC₂₅H₃₈O₅
      Structure formulaStructure formula
      Purity≥98% by HPLC
      ContaminantsHeavy metals: <20 ppm
      SolubilityDMSO or Ethanol (50 mg/ml). Dissolve 50 mg in 1 ml in ethanol and add 0.813 ml of 1N NaOH. Adjust the pH to 7.2 by adding small quantities of 1N HCl before use.
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution in ethanol-NaOH, aliquot and freeze (-20°C) Ethanol-NaOH solutions are stable for up to 1 month at -20°C. Neutralized solutions should be used immediately.
      Toxicity Standard Handling
      Merck USA index14, 8539
      ReferencesYada, T., et al. 1999. Br. J. Pharmacol. 126, 1205.
      Clutterbuck, R.D., et al. 1998. Br. J. Haematol. 102, 522.
      Yokoyama, K., et al. 1998. Mol. Biochem. Parasitol. 94, 87.
      Negre-Aminou, P., et al. 1997. Biochim. Biophys. Acta 1345, 259.
      Vrtovsnik, F., et al. 1997. Kidney Int. 52, 1016.
      Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.