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Buffer Detection Kit for Magnetic Beads
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567020
Sigma-AldrichSimvastatin - CAS 79902-63-9 - Calbiochem
A lipophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks Ras function through inhibition of farnesylation.
More>>A lipophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks Ras function through inhibition of farnesylation. Less<<
Simvastatin - CAS 79902-63-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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Description
Overview
A lipophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks Ras function through inhibition of farnesylation. Also inhibits glucose-induced Ca2+ signaling and insulin secretion by blocking L-type Ca2+ channels in rat islet β-cells. Inhibits cell proliferation of human smooth muscle cells. Note: this product is supplied in an inactive form and requires treatment with NaOH in EtOH followed by neutralization to pH 7.2 for activation.
Catalogue Number
567020
Brand Family
Calbiochem®
Synonyms
MK-733, L-Type Calcium Channel Blocker VI
References
References
Yada, T., et al. 1999. Br. J. Pharmacol. 126, 1205. Clutterbuck, R.D., et al. 1998. Br. J. Haematol. 102, 522. Yokoyama, K., et al. 1998. Mol. Biochem. Parasitol. 94, 87. Negre-Aminou, P., et al. 1997. Biochim. Biophys. Acta 1345, 259. Vrtovsnik, F., et al. 1997. Kidney Int. 52, 1016. Keyomarsi, K., et al. 1991. Cancer Res.51, 3602.
Following reconstitution in ethanol-NaOH, aliquot and freeze (-20°C) Ethanol-NaOH solutions are stable for up to 1 month at -20°C. Neutralized solutions should be used immediately.
Simvastatin - CAS 79902-63-9 - Calbiochem Certificates of Analysis
Title
Lot Number
567020
References
Reference overview
Yada, T., et al. 1999. Br. J. Pharmacol. 126, 1205. Clutterbuck, R.D., et al. 1998. Br. J. Haematol. 102, 522. Yokoyama, K., et al. 1998. Mol. Biochem. Parasitol. 94, 87. Negre-Aminou, P., et al. 1997. Biochim. Biophys. Acta 1345, 259. Vrtovsnik, F., et al. 1997. Kidney Int. 52, 1016. Keyomarsi, K., et al. 1991. Cancer Res.51, 3602.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
19-May-2008 RFH
Synonyms
MK-733, L-Type Calcium Channel Blocker VI
Description
A lipophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks Ras function through inhibition of farnesylation. Also inhibits glucose-induced Ca2+-signaling and insulin secretion by blocking L-type Ca2+ channels in rat islet β-cells. Inhibits cell proliferation of human smooth muscle cells. Note: This product is supplied in an inactive form and requires treatment with NaOH in ethanol followed by neutralization to pH 7.2 for activation.
Form
Off-white solid
CAS number
79902-63-9
RTECS
EK7798000
Chemical formula
C₂₅H₃₈O₅
Structure formula
Purity
≥98% by HPLC
Contaminants
Heavy metals: <20 ppm
Solubility
DMSO or Ethanol (50 mg/ml). Dissolve 50 mg in 1 ml in ethanol and add 0.813 ml of 1N NaOH. Adjust the pH to 7.2 by adding small quantities of 1N HCl before use.
Storage
+2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution in ethanol-NaOH, aliquot and freeze (-20°C) Ethanol-NaOH solutions are stable for up to 1 month at -20°C. Neutralized solutions should be used immediately.
Toxicity
Standard Handling
Merck USA index
14, 8539
References
Yada, T., et al. 1999. Br. J. Pharmacol. 126, 1205. Clutterbuck, R.D., et al. 1998. Br. J. Haematol. 102, 522. Yokoyama, K., et al. 1998. Mol. Biochem. Parasitol. 94, 87. Negre-Aminou, P., et al. 1997. Biochim. Biophys. Acta 1345, 259. Vrtovsnik, F., et al. 1997. Kidney Int. 52, 1016. Keyomarsi, K., et al. 1991. Cancer Res.51, 3602.
