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SCC280 SCC-61 Human Squamous Cell Carcinoma Cell Line

SCC-61 human squamous cell carcinoma cell line is a good model for studying radiation resistance in SCC cancer cells.

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SCC280
≥1X10⁶ cells/vial   
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      Overview

      Replacement Information
      Description
      Catalogue NumberSCC280
      DescriptionSCC-61 Human Squamous Cell Carcinoma Cell Line
      Alternate Names
      • SCC 61
      • SCC61
      Background InformationSquamous cell carcinoma of the head and neck (HNSCC) is the 9th-most common cancer worldwide and is characterized by a high rate of recurrence after therapy, with a median 5-year survival range of 40-50% (1). HNSCC tumors show a wide range of heterogeneity in response to radiation therapy. Cellular HNSCC models that demonstrate a range of radiation sensitivity are thus invaluable for elucidating the factors underlying radiation responses of cancer cells.

      The SCC-61 HNSCC cell line, derived from an aggressive tongue squamous cell carcinoma (2), is an established model for HNSCC. SCC-61 cells are relatively sensitive to radiation compared to other HNSCC cell lines as well as a relatively stable genome (3). SCC-61 cells grow robustly and are strongly adherent in culture. SCC-61 cells have been characterized by positive expression of the SCC marker p63 (p40) (4). SCC-61 cells have demonstrated utility in studies parsing mechanisms of radio-resistance in SCC tumor cells, as demonstrated by transformation of this cell line with factors conferring radio-resistance (5).

      Source:
      SCC-61 cell line was derived from a tongue squamous cell carcinoma of a male patient (2).

      References:
      1. J Immunother Cancer. 2019; 7(1): 184.
      2. Br J Cancer. 1984; 49(5): 595-601.
      3. Int J Radiat Oncol Biol Phys. 1991; 20(4): 733-8.
      4. Diagn Cytopathol 2009; 37(3): 178-83.
      5. Proc Natl Acad Sci USA. 2004; 101(6): 1714-9.
      References
      Product Information
      Applications
      ApplicationSCC-61 human squamous cell carcinoma cell line is a good model for studying radiation resistance in SCC cancer cells.
      Key Applications
      • Cell Culture
      Application NotesThis product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact licensing@emdmillipore.com.
      Biological Information
      Cell Line Type
      • Cancer Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assurance• Each vial contains ≥ 1X10⁶ viable cells.
      • Cells are tested negative for infectious diseases by a Human Essential CLEAR panel by Charles River Animal Diagnostic Services.
      • Cells are verified to be of human origin and negative for inter-species contamination from rat, mouse, chinese hamster, Golden Syrian hamster, and non-human primate (NHP) as assessed by a Contamination CLEAR panel by Charles River Animal Diagnostic Services.
      • Cells are negative for mycoplasma contamination.
      • Each lot of cells is genotyped by STR analysis to verify the unique identity of the cell line.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
      Packaging Information
      Material Size≥1X10⁶ cells/vial
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      SCC280 04061842104062