553513 Sigma-AldrichRac Inhibitor III, EHop-016 - CAS 1380432-32-5 - Calbiochem
Rac Inhibitor III, EHop-016, CAS 1380432-32-5, is a cell-permeable analog of NSC23766. It is ~100-fold more potent than NSC23766 in suppressing Rac1-GTP level in MDA-MB-435 cells.
More>> Rac Inhibitor III, EHop-016, CAS 1380432-32-5, is a cell-permeable analog of NSC23766. It is ~100-fold more potent than NSC23766 in suppressing Rac1-GTP level in MDA-MB-435 cells. Less<<Synonyms: N⁴-(9-Ethyl-9H-carbazol-3-yl)-N²-(3-morpholin-4-yl-propyl)-pyrimidine-2,4-diamine
Recommended Products
Overview
Key Spec Table
CAS # | Empirical Formula |
---|---|
1380432-32-5 | C₂₅H₃₀N₆O |
Pricing & Availability
Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
---|---|---|---|---|---|---|
553513-10MGCN |
|
Glass bottle | 10 mg |
|
— |
Description | |
---|---|
Overview | A cell-permeable NSC23766 (Cat. No. 553502) analog that is more selective against Rac interaction with Vav2 (by 45% blockage at 4 µM) than Tiam (35% blockage at 50 µM) and ~100-times more potent than NSC23766 in suppressing Rac1-GTP level in MDA-MB-435 (IC50 = 1.1 vs. 95 µM, respectively) cultures. Effectively inhibits PAK Thr423 phosphorylation (IC50 <2 µM), while reducing Cdc42-GTP level only at higher concentrations (by 18% at 5 µM), in MDA-MB-435 cultures. |
Catalogue Number | 553513 |
Brand Family | Calbiochem® |
Synonyms | N⁴-(9-Ethyl-9H-carbazol-3-yl)-N²-(3-morpholin-4-yl-propyl)-pyrimidine-2,4-diamine |
References | |
---|---|
References | Montalvo-Ortiz, B.L., et al. 2012. J. Biol. Chem. 287, 13228. |
Product Information | |
---|---|
CAS number | 1380432-32-5 |
Form | Pale yellow powder |
Hill Formula | C₂₅H₃₀N₆O |
Chemical formula | C₂₅H₃₀N₆O |
Structure formula Image | |
Quality Level | MQ100 |
Biological Information | |
---|---|
Purity | ≥96% by HPLC |
Packaging Information | |
---|---|
Packaged under inert gas | Packaged under inert gas |
Global Trade Item Number | |
---|---|
Catalogue Number | GTIN |
553513-10MGCN | 04055977193725 |