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851009 PyBOP

PyBOP Novabiochem®. CAS 128625-52-5, molar mass 520.39 g/mol.

PyBOP MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
CAS #: 128625-52-5 Molar Mass: 520.39 g/mol Hill Formula: C₁₈H₂₈N₆OP * F₆P
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851009
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Overview

Replacement Information

Key Spec Table

CAS #Hill FormulaMolar Mass
128625-52-5C₁₈H₂₈N₆OP * F₆P520.39 g/mol

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      8.51009.0100
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          		 Plastic bottle 100 g
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          8.51009.0500
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              8.51009.1000
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                  		 Plastic bottle 1 kg
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                  Description
                  Catalogue Number851009
                  Replaces01-62-0016
                  Brand Family Novabiochem®
                  Alternate Names
                  • Benzotriazole-1-yl-oxy-tris-pyrrolidino-phosphonium hexafluorophosphate
                  Background InformationThe standard in situ coupling reagent for solid phase peptide synthesis [1-5]. This product can replace BOP in all applications without loss of performance. Unlike uronium-based reagents, PyBOP® does not give rise to guanidinated by-products during cyclization and fragment condensation reactions.

                  The product number for this product was previously 01-62-0016.

                  To obtain a certificate of analysis (CoA) of a lot that begins with the letter "A", please select the option in the right hand menu "Request a COA for Lot#s starting with A".
                  References
                  Product Information
                  CAS number128625-52-5
                  Hill FormulaC₁₈H₂₈N₆OP * F₆P
                  Molar Mass520.39 g/mol
                  HS Code2933 99 80
                  Structure formula ImageStructure formula Image
                  Quality LevelMQ400
                  Applications
                  ApplicationPyBOP Novabiochem®. CAS 128625-52-5, molar mass 520.39 g/mol.
                  Biological Information
                  Physicochemical Information
                  Density1.438 g/cm3 (20 °C)
                  Melting Point140 - 155 °C
                  Vapor pressure<1 hPa (25 °C)
                  Dimensions
                  Materials Information
                  Toxicological Information
                  Safety Information according to GHS
                  Hazard Pictogram(s) Hazard Pictogram(s)
                  Hazard Pictogram(s)
                  Hazard Statement(s)H302: Harmful if swallowed.
                  H317: May cause an allergic skin reaction.
                  H410: Very toxic to aquatic life with long lasting effects.
                  Precautionary Statement(s)P261: Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
                  P264: Wash skin thoroughly after handling.
                  P273: Avoid release to the environment.
                  P280: Wear protective gloves.
                  P301 + P312: IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell.
                  P302 + P352: IF ON SKIN: Wash with plenty of water.
                  Signal WordWarning
                  Storage class10 - 13 Other liquids and solids
                  WGKWGK 3 highly hazardous to water
                  Safety Information
                  Categories of dangerirritant
                  Product Usage Statements
                  Storage and Shipping Information
                  StorageStore at +2°C to +8°C.
                  Packaging Information
                  Transport Information
                  Declaration (railroad and road) ADR, RIDUN 3077 , 9, III
                  Declaration (transport by air) IATA-DGRUN 3077 , 9, III
                  Declaration (transport by sea) IMDG-CodeUN 3077 , 9, III, Marine Pollutant: P
                  Supplemental Information
                  Specifications
                  Color (visual)white to slight yellow to beige
                  Appearance of substance (visual)powder
                  Identity (IR)passes test
                  Assay (HPLC, area%)≥ 99.0 % (a/a)
                  Solubility (1 mmole in 2 ml DMF)clearly soluble
                  Global Trade Item Number
                  Catalogue Number GTIN
                  8.51009.0025 04027269081089
                  8.51009.0100 04027269081096
                  8.51009.0500 04027269178611
                  8.51009.1000 04027269131296

                  Documentation

                  PyBOP SDS

                  Title

                  Safety Data Sheet (SDS) 

                  PyBOP Certificates of Analysis

                  Product Number PackagingSpecificationLot Number
                  8.51009.0025 Plastic bottlePDF Specification Document
                  8.51009.0100 Plastic bottlePDF Specification Document
                  8.51009.0500 Plastic bottlePDF Specification Document
                  8.51009.1000 Plastic bottlePDF Specification Document

                  Brochure

                  Title
                  Novabiochem Coupling Reagent Flyer 2010
                  Novabiochem Innovations 02/06
                  Novabiochem Innovations 03/10
                  Novabiochem Letters 01/14
                  ペプチド合成試薬ガイド
                  豊富なラインナップ! Novabiochemのペプチド合成用縮合剤

                  Citations

                  Title
                  • [1] J. Martinez, et al. (1985) J. Med. Chem., 28, 1874.
                  • [2] J. Coste, et al. (1990) Tetrahedron Lett., 31, 205.
                  • [3] G. B. Fields, et al. in 'Innovation & Perspectives in Solid Phase Synthesis, 1st International Symposium', R. Epton (Eds), SPCC UK Ltd., Birmingham, 1990, pp. 241.
                  • [4] T. Høeg-Jensen, et al. (1991) Tetrahedron Lett., 32, 7617.
                  • [5] R. von Eggelkraut-Gottanka, et al. (2003) Tetrahedron Lett., 44, 3551.