516483 Sigma-AldrichPepstatin A, Penetratin - Calbiochem
A Pepstatin A that is ~75% less potent against Cathespins D/E than PepA in cell-free assays.
More>> A Pepstatin A that is ~75% less potent against Cathespins D/E than PepA in cell-free assays. Less<<Pepstatin A, Penetratin - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: PepA-RQIKIWFQNRRMKWKK-OH, PepA-Antp₄₃₋₅₈
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Overview
| Replacement Information |
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Key Spec Table
| Empirical Formula |
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| C₁₃₈H₂₂₉N₃₉O₂₈S |
Pricing & Availability
| Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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| 516483-1MGCN |
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Plastic ampoule | 1 mg |
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| Description | |
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| Overview | A Pepstatin A (PepA; Cat. No. 516481) penetratin (pAntp43-58) conjugate (PepA-P) that is ~75% less potent against Cathespins D/E (IC50 = 920 nM) than PepA in cell-free assays, presumably due to its decreased solubility. However, with its enhanced permeability, PepA-P is much more active than PepA in inhibiting cellular aspartic protease activity in MCF7 (94.1% vs. 54.6% inhibition wtih 10 µM respective compound), Boleths, and Dendritic cultures. PepA-P, but not PepA, effectively interferes with antigen processing by primary APCs and the subsequent activation of antigen-specific memory T cells. |
| Catalogue Number | 516483 |
| Brand Family | Calbiochem® |
| Synonyms | PepA-RQIKIWFQNRRMKWKK-OH, PepA-Antp₄₃₋₅₈ |
| References | |
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| References | Zaidi, N., et al. 2007. Biochem. Biophys. Res. Commun. 364, 243. |
| Product Information | |
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| Form | White lyophilized solid |
| Formulation | Supplied as a trifluoroacetate salt. |
| Hill Formula | C₁₃₈H₂₂₉N₃₉O₂₈S |
| Chemical formula | C₁₃₈H₂₂₉N₃₉O₂₈S |
| Hygroscopic | Hygroscopic |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Purity | ≥97% by HPLC |
| Physicochemical Information | |
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| Peptide Sequence | PepA-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-CO₂H |
| Dimensions |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information | |
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| S Phrase | S: 22-24/25 Do not breathe dust. Avoid contact with skin and eyes. |
| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 516483-1MGCN | 04055977198843 |
Documentation
Pepstatin A, Penetratin - Calbiochem SDS
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Pepstatin A, Penetratin - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 516483 |
References
| Reference overview |
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| Zaidi, N., et al. 2007. Biochem. Biophys. Res. Commun. 364, 243. |
| Data Sheet | ||||||||||||||||||||||||||||||
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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