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516568 PPARβ/δ Inverse Agonist - Calbiochem

The PPARβ/δ Inverse Agonist controls the biological activity of PPARβ/δ.

PPARβ/δ Inverse Agonist - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: methyl 3-(N-(4-(hexylamino)-2-methoxyphenyl)sulfamoyl)thiophene-2-carboxylate (ST247)

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516568
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₉H₂₆N₂O₅S₂

Pricing & Availability

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      Description
      OverviewA cell-permeable, diaryl sulfonamide inverse agonist that demonstrates selectivity for the ligand-binding domain of the PPAR β/δ receptor (IC50 = 93 nM). Enhances the interaction of the PPARβ/δ ligand-binding domain with the co-repressor, SMRT-ID2 (EC50 = 10 nM). Down-regulates the peroxisome proliferator response elements (PPREs)-driven target gene, ANGPTL4. Inhibits PPARβ/δ- specific agonist-induced transcriptional activity in human myofibroblasts and mouse thioglycollate-elicited peritoneal macrophages.
      Catalogue Number516568
      Brand Family Calbiochem®
      Synonymsmethyl 3-(N-(4-(hexylamino)-2-methoxyphenyl)sulfamoyl)thiophene-2-carboxylate (ST247)
      References
      ReferencesNaruhn, S., et al. 2011., Mol Pharmacol. 80, 828.
      Product Information
      FormYellow solid
      Hill FormulaC₁₉H₂₆N₂O₅S₂
      Chemical formulaC₁₉H₂₆N₂O₅S₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      516568-10MGCN 04055977198218

      Documentation

      PPARβ/δ Inverse Agonist - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      PPARβ/δ Inverse Agonist - Calbiochem Certificates of Analysis

      TitleLot Number
      516568

      References

      Reference overview
      Naruhn, S., et al. 2011., Mol Pharmacol. 80, 828.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-May-2012 JSW
      Synonymsmethyl 3-(N-(4-(hexylamino)-2-methoxyphenyl)sulfamoyl)thiophene-2-carboxylate (ST247)
      DescriptionA cell-permeable, diaryl sulfonamide inverse agonist that demonstrates selectivity for the ligand-binding domain of the PPAR β/δ receptor (IC50 = 93 nM). Enhances the interaction of the PPARβ/δ ligand-binding domain with the co-repressor, SMRT-ID2 (EC50 = 10 nM). Down-regulates the peroxisome proliferator response elements (PPREs)-driven target gene, ANGPTL4. Inhibits PPARβ/δ- specific agonist-induced transcriptional activity in human myofibroblasts and mouse thioglycollate-elicited peritoneal macrophages.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₉H₂₆N₂O₅S₂
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml; clear, amber-yellow solution)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesNaruhn, S., et al. 2011., Mol Pharmacol. 80, 828.