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529598 PP1 Analog IV, 3-IB-PP1 - CAS 1174182-24-1 - Calbiochem

A cell-permeable enlarged PP1 analog that acts as a potent, ATP-competitive and reversible inhibitor of asAkt1/2/3.

PP1 Analog IV, 3-IB-PP1 - CAS 1174182-24-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-Iodobenzyl PP1 analog

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529598
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1174182-24-1C₁₆H₁₈IN₅

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      Description
      OverviewA cell-permeable enlarged PP1 (Cat. No. 567809) analog that acts as a potent, ATP-competitive and reversible inhibitor of asAkt1/2/3 (IC50 = 28, 240 and 120 nM, respectively) over wtAkt1/2/3 (IC50 = >10 µM). Shown to hyperphosphorylate Akt-Ser473 and -Thr308 in HEK293 cells coexpressed with myr-HA-asAkt1 or myr-HA-asAkt1/2/3 with no effect on pGSK-3βSer9 levels and wtAkt expressing cells. Also, specifically blocks the inhibitory function of membrane asCsk with diminished activity towards wtCsk, induces phosphorylation of Lck-Tyr394 and ERK1/2 in primary mouse T cells (EC50 ~0.5 µM) and rapidly activates T cell receptor signaling.
      Catalogue Number529598
      Brand Family Calbiochem®
      Synonyms3-Iodobenzyl PP1 analog
      References
      ReferencesSchoenborn, J.R., et al. 2011. Sci. Signal. 4, ra59.
      Okuzumi, T., et al. 2009. Nat. Chem. Bio. 5, 484.
      Product Information
      CAS number1174182-24-1
      FormWhite powder
      Hill FormulaC₁₆H₁₈IN₅
      Chemical formulaC₁₆H₁₈IN₅
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      529598-10MGCN 04055977269918

      Documentation

      PP1 Analog IV, 3-IB-PP1 - CAS 1174182-24-1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      PP1 Analog IV, 3-IB-PP1 - CAS 1174182-24-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      529598

      References

      Reference overview
      Schoenborn, J.R., et al. 2011. Sci. Signal. 4, ra59.
      Okuzumi, T., et al. 2009. Nat. Chem. Bio. 5, 484.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-August-2012 JSW
      Synonyms3-Iodobenzyl PP1 analog
      DescriptionA cell-permeable enlarged PP1 (Cat. No. 567809) analog that acts as a potent, ATP-competitive and reversible inhibitor of asAkt1/2/3 (IC50 = 28, 240 and 120 nM, respectively) over wtAkt1/2/3 (IC50 = >10 µM). Shown to hyperphosphorylate Akt-Ser473 and -Thr308 in HEK293 cells coexpressed with myr-HA-asAkt1 or myr-HA-asAkt1/2/3 with no effect on pGSK-3βSer9 levels and wtAkt expressing cells. Also, specifically blocks the inhibitory function of membrane asCsk with diminished activity towards wtCsk, induces phosphorylation of Lck-Tyr394 and ERK1/2 in primary mouse T cells (EC50 ~0.5 µM) and rapidly activates T cell receptor signaling.
      FormWhite powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1174182-24-1
      Chemical formulaC₁₆H₁₈IN₅
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (0.5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesSchoenborn, J.R., et al. 2011. Sci. Signal. 4, ra59.
      Okuzumi, T., et al. 2009. Nat. Chem. Bio. 5, 484.