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370655 PKG Iα Inhibitor, Cell-Permeable - Calbiochem

The PKG Iα Inhibitor, Cell-Permeable controls the biological activity of PKG Iα. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

PKG Iα Inhibitor, Cell-Permeable - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: DT-3, RQIKIWFQNRRMKWKKLRKKKKKH, PKG Inhibitor VIII

Primary Target: PKG1α
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370655
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₅₂H₂₅₈N₅₂O₂₈S

Pricing & Availability

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      Description
      OverviewA highly potent, reversible, and substrate competitive membrane-permeable Drosophila Antennapedia homeodomain fused-peptide that selectively inhibits protein kinase G Iα (Ki = 25 nM). Shown to efficiently translocate into arterial smooth muscle cells and inhibit NO-induced vasodilation (ED50 = 47 µM). Inhibits protein kinase A at much higher concentrations (Ki = 493 µM). The carrier peptide is also available under Cat. no. 287895.
      Catalogue Number370655
      Brand Family Calbiochem®
      SynonymsDT-3, RQIKIWFQNRRMKWKKLRKKKKKH, PKG Inhibitor VIII
      References
      ReferencesDostmann, W. R.G., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 14772.
      Product Information
      ATP CompetitiveY
      FormLyophilized
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₁₅₂H₂₅₈N₅₂O₂₈S
      Chemical formulaC₁₅₂H₂₅₈N₅₂O₂₈S
      Hygroscopic Hygroscopic
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPKG1α
      Primary Target K<sub>i</sub>25 nM against protein kinase G Iα
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceH-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Leu-Arg-Lys-Lys-Lys-Lys-Lys-His-OH
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      370655-1MGCN 04055977191653

      Documentation

      PKG Iα Inhibitor, Cell-Permeable - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      PKG Iα Inhibitor, Cell-Permeable - Calbiochem Certificates of Analysis

      TitleLot Number
      370655

      References

      Reference overview
      Dostmann, W. R.G., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 14772.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-January-2010 RFH
      SynonymsDT-3, RQIKIWFQNRRMKWKKLRKKKKKH, PKG Inhibitor VIII
      DescriptionA highly potent, reversible, and substrate competitive membrane-permeable peptide that selectively inhibits protein kinase G Iα (PKG Iα) (Ki = 25 nM). Inhibitor peptide is fused to the Drosophila Antennapedia homeo domain peptide to allow membrane permeability. Shown to efficiently cross the membrane of arterial smooth muscle cells and inhibit nitric oxide-induced (NO-induced) vasodilation (EC50 = 47 µM). Inhibits protein kinase A (PKA) activity only at much higher concentrations (Ki = 493 µM). The carrier peptide is also available under Cat. no. 287895.
      FormLyophilized
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₅₂H₂₅₈N₅₂O₂₈S
      Peptide SequenceH-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Leu-Arg-Lys-Lys-Lys-Lys-Lys-His-OH
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Toxicity Standard Handling
      ReferencesDostmann, W. R.G., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 14772.