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AG231 Neurofilament 70 kDa, porcine

Neurofilament 70 kDa, porcine MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Key Applications: Positive Control UniProt Number: P02547 Entrez Gene Number: 100521224
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AG231
100 µg  
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      Overview

      Replacement Information
      Description
      Catalogue NumberAG231
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionNeurofilament 70 kDa, porcine
      OverviewPurified porcine axonal neurofilament 70 (low molecular weight, NF-L).
      References
      Product Information
      PresentationLiquid in 6M Urea, 10 mM Phosphate, pH 7.5.
      Quality LevelMQ100
      Applications
      Key Applications
      • Positive Control
      Application NotesWestern blotting

      Protein standard

      ELISA

      Radioimmunoassay

      Optimal working dilution must be determined by the end user.
      Biological Information
      Concentration1 mg/mL
      PurityContains approximately 90% NF-L and a small amount of NF-M.
      Entrez Gene Number
      Gene Symbol
      • NEFL
      • CMT1F
      • NF-L
      • NF68
      • CMT2E
      • NFL
      UniProt Number
      UniProt SummaryFUNCTION: Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber.
      SIZE: 549 amino acids; 62072 Da
      DOMAIN: The extra mass and high charge density that distinguish the neurofilament proteins from all other intermediate filament proteins are due to the tailpiece extensions. This region may form a charged scaffolding structure suitable for interaction with other neuronal components or ions.
      PTM: O-glycosylated (By similarity).
      DISEASE: Defects in NEFL are the cause of Charcot-Marie-Tooth disease type 1F (CMT1F) [MIM:607734]. CMT1F is a form of Charcot- Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy or CMT1, and primary peripheral axonal neuropathy or CMT2. Neuropathies of the CMT1 group are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet. CMT1F is characterized by onset in infancy or childhood (range 1 to 13 years). & Defects in NEFL are the cause of Charcot-Marie-Tooth disease type 2E (CMT2E) [MIM:607684]. CMT2E is an autosomal dominant form of Charcot-Marie-Tooth disease type 2. Neuropathies of the CMT2 group are characterized by signs of axonal regeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy.
      SIMILARITY: Belongs to the intermediate filament family.
      MISCELLANEOUS: NF-L is the most abundant of the three neurofilament proteins and, as the other nonepithelial intermediate filament proteins, it can form homopolymeric 10-nm filaments.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C to -70°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AG231 04053252406232

      Documentation

      Neurofilament 70 kDa, porcine SDS

      Title

      Safety Data Sheet (SDS) 

      Neurofilament 70 kDa, porcine Certificates of Analysis

      TitleLot Number
      NEUROFILAMENT 70, PORCINE PURIFIED PROTEIN - 2436306 2436306
      NEUROFILAMENT 70, PORCINE - 3145029 3145029
      NEUROFILAMENT 70, PORCINE - 3587163 3587163
      NEUROFILAMENT 70, PORCINE - 3891418 3891418
      NEUROFILAMENT 70, PORCINE - 4034706 4034706
      NEUROFILAMENT 70, PORCINE - 4132469 4132469
      NEUROFILAMENT 70, PORCINE -2766392 2766392
      NEUROFILAMENT 70, PORCINE -2822807 2822807
      NEUROFILAMENT 70, PORCINE PURIFIED PROTEIN 3047042
      NEUROFILAMENT 70, PORCINE PURIFIED PROTEIN - 1921340 1921340
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      Data Sheet

      Title
      NEUROFILAMENT 70, PORCINE PURIFIED PROTEIN