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FCABS400F Milli-Mark® Anti-FcεRI Antibody, γ subunit-FITC

Milli-Mark Anti-FcεRI Antibody, γ subunit-FITC is an antibody against FcεRI for use in FC.

Milli-Mark® Anti-FcεRI Antibody, γ subunit-FITC MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Research Sub-Category: Inflammation & Autoimmune Mechanisms Gene Symbol: FCER1G, OTTHUMP00000063478 UniProt Number: P30273
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FCABS400F
100 tests  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R, H, MFCRbFITCPolyclonal Antibody
      Description
      Catalogue NumberFCABS400F
      Trade Name
      • Milli-Mark
      DescriptionMilli-Mark® Anti-FcεRI Antibody, γ subunit-FITC
      Alternate Names
      • Fc fragment of IgE high affinity I receptor for gamma polypeptide
      • Fc-epsilon RI-gamma
      • FceRI gamma
      • IgE Fc receptor subunit gamma
      • Immunoglobulin E receptor, high affinity,gamma chain
      Background InformationType I allergic reactions are mediated through the IgE high affinity receptor (FceRI). When a multivalent antigen is presented, a redistribution of the monomeric IgE FceRI receptor complexes cause the degranulation of mast cells and basophils, resulting in the subsequent release of factors responsible for type I allergic reactions. The FceRI receptor is a tetrameric complex, consisting of an a-chain, b-chain and a dimeric g-chain. While the a-chain is primarily involved with the binding of IgE, the signal is transferred through the g subunit, which contains the immunoreceptor tyrosine activation motifs (ITAM) critical for initiating receptor mediated signal transduction through the Syk and Lyn tyrosine kinases. The FceRI receptor is able to engage and disengage the IgE, providing a versatile model for studying the function of kinase coupled receptors.
      References
      Product Information
      FormatFITC
      Control
      • RBL cells
      PresentationPurified rabbit polyclonal IgG conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA.
      Quality LevelMQ100
      Applications
      ApplicationMilli-Mark Anti-FcεRI Antibody, γ subunit-FITC is an antibody against FcεRI for use in FC.
      Key Applications
      • Flow Cytometry
      Biological Information
      ImmunogenSynthetic peptide corresponding to amino acids 80-86 of γ-subunit of Fc receptors.
      HostRabbit
      SpecificityRecognizes and is specific for FcεRI, γ-subunit.
      IsotypeIgG
      Species Reactivity
      • Rat
      • Human
      • Mouse
      Species Reactivity NoteShown to demonstrated to work on Rat. Unconjugated antibody (Cat No. 06-727) has been shown to work on Human and Mouse.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe IgE receptor plays a central role in allergic disease, coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma. The allergic response occurs when 2 or more high-affinity IgE receptors are crosslinked via IgE molecules that in turn are bound to an allergen (antigen) molecule. A perturbation occurs that brings about the release of histamine and proteases from the granules in the cytoplasm of the mast cell and leads to the synthesis of prostaglandins and leukotrienes--potent effectors of the hypersensitivity response. The IgE receptor consists of 3 subunits: alpha, beta (MIM 147138), and gamma (MIM 147139); only the alpha subunit is glycosylated.
      Gene Symbol
      • FCER1G
      • OTTHUMP00000063478
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P30273 # The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface.

      SIZE: 86 amino acids; 9667 Da

      SUBUNIT: IgE Fc receptor is a tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. The gamma chain from Fc-epsilon-Ri are also subunits of other Fc receptors.

      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

      SIMILARITY: SwissProt: P30273 ## Belongs to the CD3Z/FCER1G family. & Contains 1 ITAM domain.
      Molecular Weight10 kDa Calculated
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by flow cytometry using RBL cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
      Packaging Information
      Material Size100 tests
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      FCABS400F 04053252757730

      Documentation

      Milli-Mark® Anti-FcεRI Antibody, γ subunit-FITC SDS

      Title

      Safety Data Sheet (SDS) 

      Milli-Mark® Anti-FcεRI Antibody, γ subunit-FITC Certificates of Analysis

      TitleLot Number
      Milli-Mark Anti-Fc#949;RI, #947; subunit-FITC - 2110508 2110508
      Milli-Mark Anti-Fc#949;RI, #947; subunit-FITC - 2148272 2148272
      Milli-Mark Anti-Fc#949;RI, #947; subunit-FITC - 2167760 2167760
      Milli-Mark Anti-FcRI, subunit-FITC - 2199681 2199681
      Milli-Mark Anti-FcRI, subunit-FITC - 2219398 2219398
      Milli-Mark#174; Anti-FcRI, subunit-FITC - 2022624 2022624
      Milli-Mark#174; Anti-FcRI, subunit-FITC - 2032725 2032725
      Milli-Mark#174; Anti-FcRI, subunit-FITC - 2066316 2066316
      Milli-Mark#174; Anti-FcRI, subunit-FITC - 2106930 2106930
      Milli-Mark#174; Anti-FcRI, subunit-FITC - Q1964938 Q1964938
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      Related Products & Applications

      Related Products

      Catalogue Number Description  
      06-727 Anti-FcεRI Antibody, γ subunit Show Pricing & Availability

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      Milli-Mark™

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies