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474790 MG-132 - CAS 133407-82-6 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
133407-82-6C₂₆H₄₁N₃O₅

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474790-10MGCN
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      474790-1MGCN
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          Plastic ampoule 1 mg
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          474790-20MGCN
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              20 mg
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              474790-5MGCN
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                  Description
                  OverviewA potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM). Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis. Inhibits NF-κB activation (IC50 = 3 µM). Also reported to increases the survival rate of mesenchymal stem cells following their transplantation. Prevents β-secretase cleavage. A 10 mM (1 mg/210 µl) solution of MG-132 (Cat. No. 474791) in DMSO is also available. This material is ≥98% pure by HPLC. A material with ≥95% purity by HPLC (Cat. No. 474787) is also available.
                  Catalogue Number474790
                  Brand Family Calbiochem®
                  SynonymsCarbobenzoxy-L-leucyl-L-leucyl-L-leucinal, Z-LLL-CHO, Proteasome Inhibitor XI
                  References
                  ReferencesLi, Z.W. et al. 2011. Sheng Li Xue Bao. 63, 525.
                  Steinhilb, M.L., et al. 2001. J. Biol. Chem. 276, 4476.
                  Meriin, A.B., et al. 1998. J. Biol. Chem. 273, 6373.
                  Adams, J., and Stein, R. 1996. Ann. Rep. Med. Chem. 31, 279.
                  Klafki, H.W., et al. 1996. J. Biol. Chem. 271, 2865.
                  Lee, D.H., and Goldberg, A.L., 1996. J. Biol. Chem. 271, 27280.
                  Wiertz, E.J., et al. 1996. Cell 84, 769.
                  Jensen, T.J., et al. 1995. Cell 83, 129.
                  Read, M.A., et al. 1995. Immunity 2, 493.
                  Rock, K.L., et al. 1994. Cell 78, 761.
                  Product Information
                  CAS number133407-82-6
                  ATP CompetitiveN
                  FormWhite solid
                  Hill FormulaC₂₆H₄₁N₃O₅
                  Chemical formulaC₂₆H₄₁N₃O₅
                  ReversibleY
                  Structure formula ImageStructure formula Image
                  Quality LevelMQ100
                  Biological Information
                  Primary Targetproteasome
                  Primary Target IC<sub>50</sub>3 µM against NF-κB activation
                  Primary Target K<sub>i</sub>4 nM against proteasome
                  Purity≥98% by HPLC
                  Physicochemical Information
                  Cell permeableY
                  Peptide SequenceZ-Leu-Leu-Leu-CHO
                  Storage and Shipping Information
                  Ship Code Ambient Temperature Only
                  Toxicity Standard Handling
                  Storage -20°C
                  Do not freeze Ok to freeze
                  Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
                  Global Trade Item Number
                  Catalogue Number GTIN
                  474790-10MGCN 04055977185485
                  474790-1MGCN 07790788050436
                  474790-20MGCN 04055977185492
                  474790-5MGCN 07790788050443