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407652 Sigma-AldrichInterleukin-6, Human, Recombinant, E. coli

Interleukin-6, Human, Recombinant, E. coli MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

SDS
CoA
References
Data Sheet

Synonyms: rhIL-6

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Overview

Replacement Information

Pricing & Availability

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Description
Overview	Recombinant, human, interleukin-6 expressed in E. coli. A prototypic pleiotrophic, pro-inflammatory cytokine that stimulates the production of acute phase proteins by hepatocytes. Also known to induce skeletal muscle protein breakdown. Induces growth and differentiation of B cells, T cells, and hepatocytes. Stimulates growth and inhibits constitutive, protein synthesis-independent apoptosis of murine B cell hybridoma 7TD1. IL-6 is produced by macrophages, endothelial cells, and activated T helper cells. Also considered as a potential marker of adipocyte differentiation. Human IL-6 is active on murine cells.
Catalogue Number	407652
Brand Family	Calbiochem®
Synonyms	rhIL-6

References
References	Vicennati, V., et al. 2002. Int. J. Obes. Relat. Metab. Disord. 26, 9. Vallieres, L., and Rivest, S. 1999. Endocrinology 140, 3890. Goodman, M.N. 1994. Proc. Soc. Exp. Biol. Med. 205, 182. Liu, J., et al. 1994. Cell Immunol. 155, 229. Van Snick, J. 1990. Annu. Rev. Immunol. 8, 253.

Product Information
Form	Lyophilized
Formulation	Carrier free.
Quality Level	MQ100

Applications

Biological Information
Biological activity	8-20 pg/ml as measured in a cell proliferation assay with a factor-dependent murine plasmacytoma cell line, B9.
Purity	≥95% by SDS-PAGE

Physicochemical Information
Contaminants	Endotoxin: ≤1.0 EU/µg IL-6

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	≤ -70°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C. Avoid freeze/thaw cycles of solutions.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
Catalogue Number	GTIN
407652-10UGCN	04055977211405

Documentation

Interleukin-6, Human, Recombinant, E. coli SDS

Title
Safety Data Sheet (SDS)

Interleukin-6, Human, Recombinant, E. coli Certificates of Analysis

Title	Lot Number
407652	Enter Lot Number

References

Reference overview
Vicennati, V., et al. 2002. Int. J. Obes. Relat. Metab. Disord. 26, 9. Vallieres, L., and Rivest, S. 1999. Endocrinology 140, 3890. Goodman, M.N. 1994. Proc. Soc. Exp. Biol. Med. 205, 182. Liu, J., et al. 1994. Cell Immunol. 155, 229. Van Snick, J. 1990. Annu. Rev. Immunol. 8, 253.

Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	26-October-2007 JSW
Synonyms	rhIL-6
Description	Recombinant, human, interleukin-6 expressed in E. coli. Interleukin-6 is a protein produced by a number of cell types including T-lymphocytes, monocytes, diploid fibroblasts, hepatocytes, cardiac myxomas, certain cervical cancer cells, bladder cell carcinomas, vascular endothelial cells, and human myelomas. It has a variety of biological effects and does not show a high degree of species specificity. Stimulates the production of acute phase proteins by hepatocytes. Also known to induce skeletal muscle protein breakdown. Induces growth and differentiation of B-cells, T-cells, and hepatocytes. Stimulates growth and inhibits constitutive protein synthesis-independent apoptosis of murine B-cell hybridoma 7TD1. Human sequence IL-6 is active on murine cells. 1 µg is equivalent to 7.0 x 10³ WHO units.
Form	Lyophilized
Formulation	Carrier free.
Purity	≥95% by SDS-PAGE
Contaminants	Endotoxin: ≤1.0 EU/µg IL-6
Biological activity	8-20 pg/ml as measured in a cell proliferation assay with a factor-dependent murine plasmacytoma cell line, B9.
Solubility	Reconstitute to 0.1-1.0 mg/ml in 100 mM acetic acid.
Storage	≤ -70°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C. Avoid freeze/thaw cycles of solutions.
Toxicity	Standard Handling
References	Vicennati, V., et al. 2002. Int. J. Obes. Relat. Metab. Disord. 26, 9. Vallieres, L., and Rivest, S. 1999. Endocrinology 140, 3890. Goodman, M.N. 1994. Proc. Soc. Exp. Biol. Med. 205, 182. Liu, J., et al. 1994. Cell Immunol. 155, 229. Van Snick, J. 1990. Annu. Rev. Immunol. 8, 253.

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