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GF337 IL-4,
Human Recombinant Animal Free

IL-4,
Human Recombinant Animal Free MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
UniProt Number: P05112
View This Product on Sigma-Aldrich
GF337
20µg  
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      Overview

      Replacement Information

      Key Spec Table

      SourcePurity
      Protein is expressed in E.coli.
      The protein is manufactured without the use of any animal products/reagents and is considered Animal-Free and can be used in protocols where possible transmisson of animal viruses and contamination must be avoided.      		Product endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
      Description
      Catalogue NumberGF337
      DescriptionIL-4,
      Human Recombinant Animal Free
      Alternate Names
      • Interleukin-4
      • IL4
      Background InformationIL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naïve CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergy.
      Recombinant human IL-4 is a 15.1 kDa globular protein containing 130 amino acid residues.
      References
      Product Information
      PresentationProduct is presented without additives and is filtered through a 0.2 micron filter before lyophilization.
      Quality LevelMQ100
      Applications
      Biological Information
      PurityProduct endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
      SourceProtein is expressed in E.coli.
      The protein is manufactured without the use of any animal products/reagents and is considered Animal-Free and can be used in protocols where possible transmisson of animal viruses and contamination must be avoided.
      UniProt Number
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceDetermined by its ability to stimulate the proliferation of human TF-1 cells. The expected ED50 is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 10^6 units/mg.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at -20°C for up to 4 months from date of receipt Centrifuge the vial prior to opening.
      Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein and store in working aliquots at -20°C.
      Packaging Information
      Material Size20µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      GF337 04053252979385

      Documentation

      IL-4,
      Human Recombinant Animal Free SDS

      Title

      Safety Data Sheet (SDS) 

      IL-4,
      Human Recombinant Animal Free Certificates of Analysis

      TitleLot Number
      IL-4, Human Recombinant Animal Free - Q2445317 Q2445317
      IL-4, -2799057 2799057
      IL-4, Human Recombinant Animal Free - 3062245 3062245
      IL-4, Human Recombinant Animal Free - 3290402 3290402
      IL-4, Human Recombinant Animal Free - 3389897 3389897
      IL-4, Human Recombinant Animal Free - 3446264 3446264
      IL-4, Human Recombinant Animal Free - 3549787 3549787
      IL-4, Human Recombinant Animal Free - 3671735 3671735
      IL-4, Human Recombinant Animal Free - 3782173 3782173
      IL-4, Human Recombinant Animal Free - 3837030 3837030
      Show more

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      Life Science Research > Cell Culture and Systems > Cell Culture Media and Supplements > Cell Culture Supplements > Cytokines & Growth Factors