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Merck

385880

Hsp25 Kinase Inhibitor

The Hsp25 Kinase Inhibitor controls the biological activity of Hsp25 KInase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym(s):

Hsp25 Kinase Inhibitor, KKKALNRQLGVAA, MK2 Inhibitor, MAPKAP Kinase-2 Inhibitor, MK2 Inhibitor, KKKALNRQLGVAA, MAPKAP Kinase-2 Inhibitor

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About This Item

Empirical Formula (Hill Notation):
C61H113N21O16
Molecular Weight:
1396.68
NACRES:
NA.77
UNSPSC Code:
12352200

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Product Name

Hsp25 Kinase Inhibitor, The Hsp25 Kinase Inhibitor controls the biological activity of Hsp25 KInase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

assay

≥98% (HPLC)

form

lyophilized solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

color

white

solubility

DMSO: soluble
water: soluble

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Related Categories

Other Notes

H-Lys-Lys-Lys-Ala-Leu-Asn-Arg-Gln-Leu-Gly-Val-Ala-Ala-OH
Katsoulidis, E., et al. 2005. Cancer Res.65, 9029.
Hayess, K., and Benndorf, R. 1997. Biochem. Pharmacol. 53, 1239.

Physical form

Supplied as a trifluoroacetate salt.

Preparation Note

Following recosntitution, aliquot and freeze (-20°C). Stock solutions are stable for up to months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Biochem/physiol Actions

Cell permeable: yes
Primary Target
(Hsp25) kinase
Product does not compete with ATP.
Reversible: no
Target Ki: 8.1 µM against (Hsp25) kinase

Disclaimer

Toxicity: Standard Handling (A)

General description

A 13-residue, cell-permeable peptide that acts as a potent and selective inhibitor of mammalian heat-shock protein (Hsp25) kinase. Inhibits Hsp25 kinase competitively with respect to the substrate peptide (Ki = 8.1 µM) and non-competitive with respect to ATP (Ki = 134 µM). [Hsp 25 kinase is also called mitogen-activated protein kinase-activated protein kinase-2 (MK2).]

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Global Trade Item Number

SKUGTIN
385880-1MGCN04055977190311

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