538099 Sigma-AldrichGS-493 - Calbiochem
A cell-active, bioavailable, efficacious SHP2 inhibitor. Retards cancer cell mobility & invasiveness, and prevents tumor growth in a xenograft mouse model.
More>> A cell-active, bioavailable, efficacious SHP2 inhibitor. Retards cancer cell mobility & invasiveness, and prevents tumor growth in a xenograft mouse model. Less<<GS-493 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: 4-((2Z)-2-(1,3-bis(4-Nitrophenyl)-5-oxo-1,5-dihydro-4H-pyrazol-4-yliden)hydrazino)benzenesulfonic acid, (Z)-4-(2-(1,3-bis(4-Nitrophenyl)-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)benzenesulfonic acid, SHP2 Inhibitor VII
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Overview
Key Spec Table
| Empirical Formula |
|---|
| C₂₁H₁₄N₆O₈S |
Pricing & Availability
| Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
|---|---|---|---|---|---|---|
| 5.38099.0001 |
|
Glass bottle | 10 mg |
|
— |
| Description | |
|---|---|
| Overview | A cell-permeable, bioavailable, non-toxic p-nitro analog of PHPS1 (Cat. No. 540213) that exhibits enhanced potency and selectivity. Acts as a phosphotyrosine mimetic, substrate-competitive and reversible catalytic domain inhibitor of SHP2 (IC50 = 0.071, 2.08 & 3.17 µM for SHP2, SHP1 & PTP1B, respectively). Dose-dependently reverts HGF-stimulatd epithelial-mesenchymal transition of HPAF II cells and blocks human lung adenocarcinoma LXFA 526L anchorage-independent growth. Shown to significantly retard LXFA 526L xenografted tumor growth in mice (46 mg/kg/day, i.p., q.d.). Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water. |
| Catalogue Number | 538099 |
| Brand Family | Calbiochem® |
| Synonyms | 4-((2Z)-2-(1,3-bis(4-Nitrophenyl)-5-oxo-1,5-dihydro-4H-pyrazol-4-yliden)hydrazino)benzenesulfonic acid, (Z)-4-(2-(1,3-bis(4-Nitrophenyl)-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)benzenesulfonic acid, SHP2 Inhibitor VII |
| Description | GS-493 |
| References | |
|---|---|
| References | Grosskopf, S., et al. 2015. ChemMedChem. 10, 815. |
| Product Information | |
|---|---|
| Form | Orange solid |
| Hill Formula | C₂₁H₁₄N₆O₈S |
| Reversible | Y |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Primary Target | SHP2 |
| Primary Target IC<sub>50</sub> | 0.071, 2.08 & 3.17 µ |
| Purity | ≥98% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 5.38099.0001 | 04054839119538 |