538099 Sigma-AldrichGS-493 - Calbiochem
A cell-active, bioavailable, efficacious SHP2 inhibitor. Retards cancer cell mobility & invasiveness, and prevents tumor growth in a xenograft mouse model.
More>> A cell-active, bioavailable, efficacious SHP2 inhibitor. Retards cancer cell mobility & invasiveness, and prevents tumor growth in a xenograft mouse model. Less<<Synonyms: 4-((2Z)-2-(1,3-bis(4-Nitrophenyl)-5-oxo-1,5-dihydro-4H-pyrazol-4-yliden)hydrazino)benzenesulfonic acid, (Z)-4-(2-(1,3-bis(4-Nitrophenyl)-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)benzenesulfonic acid, SHP2 Inhibitor VII
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Overview
Key Spec Table
Empirical Formula |
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C₂₁H₁₄N₆O₈S |
Pricing & Availability
Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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5.38099.0001 |
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Glass bottle | 10 mg |
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Description | |
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Overview | A cell-permeable, bioavailable, non-toxic p-nitro analog of PHPS1 (Cat. No. 540213) that exhibits enhanced potency and selectivity. Acts as a phosphotyrosine mimetic, substrate-competitive and reversible catalytic domain inhibitor of SHP2 (IC50 = 0.071, 2.08 & 3.17 µM for SHP2, SHP1 & PTP1B, respectively). Dose-dependently reverts HGF-stimulatd epithelial-mesenchymal transition of HPAF II cells and blocks human lung adenocarcinoma LXFA 526L anchorage-independent growth. Shown to significantly retard LXFA 526L xenografted tumor growth in mice (46 mg/kg/day, i.p., q.d.). Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water. |
Catalogue Number | 538099 |
Brand Family | Calbiochem® |
Synonyms | 4-((2Z)-2-(1,3-bis(4-Nitrophenyl)-5-oxo-1,5-dihydro-4H-pyrazol-4-yliden)hydrazino)benzenesulfonic acid, (Z)-4-(2-(1,3-bis(4-Nitrophenyl)-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)benzenesulfonic acid, SHP2 Inhibitor VII |
Description | GS-493 |
References | |
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References | Grosskopf, S., et al. 2015. ChemMedChem. 10, 815. |
Product Information | |
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Form | Orange solid |
Hill Formula | C₂₁H₁₄N₆O₈S |
Reversible | Y |
Quality Level | MQ100 |
Biological Information | |
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Primary Target | SHP2 |
Primary Target IC<sub>50</sub> | 0.071, 2.08 & 3.17 µ |
Purity | ≥98% by HPLC |
Physicochemical Information | |
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Cell permeable | Y |
Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
Global Trade Item Number | |
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Catalogue Number | GTIN |
5.38099.0001 | 04054839119538 |