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GF322 GDNF, Human Recombinant
Animal Free

GDNF, Human Recombinant
Animal Free MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
UniProt Number: P39905
View This Product on Sigma-Aldrich
GF322
10µg  
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      Overview

      Replacement Information

      Key Spec Table

      SourcePurity
      Protein is expressed in E.coli.
      The protein is manufactured without the use of any animal products/reagents and is considered Animal-Free and can be used in protocols where possible transmisson of animal viruses and contamination must be avoided.      		Product endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
      Description
      Catalogue NumberGF322
      DescriptionGDNF, Human Recombinant
      Animal Free
      Alternate Names
      • Glial Derived Neurotrophic Factor
      Background InformationGDNF is a disulfide-linked homodimeric neurotrophic factor structurally related to Artemin, Neurturin and Persephin. These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. GDNF signals through a multicomponent receptor system, composed of a RET and one of the four GFRα (α1-α4) receptors. GDNF specifically promotes dopamine uptake and survival and morphological differentiation of midbrain neurons. Using Parkinson’s disease mouse model, GDNF has been shown to improve conditions such as bradykinesia, rigidity, and postural instability.
      The functional human GDNF ligand is a disulfide-linked homodimer, of two 15 kDa polypeptide chains called monomers. Each monomer contains seven conserved cysteine residues, one of which (Cys 101) is used for inter-chain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine knot configuration.
      References
      Product Information
      PresentationProduct is presented in 10 mM Sodium Citrate + 150 mM NaCl and is filtered through a 0.2 micron filter before lyophilization.
      Quality LevelMQ100
      Applications
      Biological Information
      PurityProduct endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
      SourceProtein is expressed in E.coli.
      The protein is manufactured without the use of any animal products/reagents and is considered Animal-Free and can be used in protocols where possible transmisson of animal viruses and contamination must be avoided.
      UniProt Number
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceThe ED50 was determined by the proliferation of rat C6 cells is ≤ 0.1 µg/ml, corresponding to a specific activity of ≥ 1 x 10^5 units/mg.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at -20°C for up to 4 months from date of receipt Centrifuge the vial prior to opening.
      Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein and store in working aliquots at -20°C.
      Packaging Information
      Material Size10µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      GF322 04053252979620

      Documentation

      GDNF, Human Recombinant
      Animal Free SDS

      Title

      Safety Data Sheet (SDS) 

      GDNF, Human Recombinant
      Animal Free Certificates of Analysis

      TitleLot Number
      GDNF, Human Recombinant Animal Free - Q2436471 Q2436471
      GDNF, Human Recombinant - 3503862 3503862
      GDNF, Human Recombinant -2709054 2709054
      GDNF, Human Recombinant Animal Free - 3257048 3257048
      GDNF, Human Recombinant Animal Free - 3293724 3293724
      GDNF, Human Recombinant Animal Free - 3410079 3410079
      GDNF, Human Recombinant Animal Free - 3437315 3437315
      GDNF, Human Recombinant Animal Free - 3458522 3458522
      GDNF, Human Recombinant Animal Free - 3501006 3501006
      GDNF, Human Recombinant Animal Free - 3524850 3524850
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