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344101 FSB - CAS 891180-93-1 - Calbiochem

A fluorine analog of the amyloidophilic fluorescent probe BSB that crosses the blood-brain barrier and displays low toxicity.

FSB - CAS 891180-93-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (E,E)-1-Fluoro-2,5-bis(3-hydroxycarbonyl-4-hydroxy)styrylbenzene

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344101
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
760988-03-2C₂₄H₁₇FO₆

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      Description
      OverviewA fluorine analog of the amyloidophilic fluorescent probe BSB (Cat. No. 286895) that crosses the blood-brain barrier and displays low toxicity (LD50 > 80 mg/kg). Suitiable for non-invasive amyloid visualization in living transgenic Tg2576 mice by using 19F and 1H-MRI (Magnetic Resonance Imaging). Also useful for staining plaques and neurofibrillary tangles in brain tissue sections of Alzheimer's diseased patients with improved sensitivity, and reduced background.
      Catalogue Number344101
      Brand Family Calbiochem®
      Synonyms(E,E)-1-Fluoro-2,5-bis(3-hydroxycarbonyl-4-hydroxy)styrylbenzene
      References
      ReferencesHiguchi, M., et al. 2005. Nat. Neurosci. 8, 527.
      Sato, K., et al. 2004. Eur. J. Med. Chem. 39, 573.
      Product Information
      CAS number760988-03-2
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₂₄H₁₇FO₆
      Chemical formulaC₂₄H₁₇FO₆
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetAmyloidophilic fluorescent probe
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      344101-5MGCN 04055977215205

      Documentation

      FSB - CAS 891180-93-1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      FSB - CAS 891180-93-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      344101

      References

      Reference overview
      Higuchi, M., et al. 2005. Nat. Neurosci. 8, 527.
      Sato, K., et al. 2004. Eur. J. Med. Chem. 39, 573.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-June-2008 RFH
      Synonyms(E,E)-1-Fluoro-2,5-bis(3-hydroxycarbonyl-4-hydroxy)styrylbenzene
      DescriptionA fluorine analog of the amyloidophilic fluorescent probe BSB (Cat. No. 286895) that crosses the blood-brain barrier and displays low toxicity (LD50 >80 mg/kg). Suitable for non-invasive amyloid visualization in living transgenic Tg2576 mice by using 19F and 1H-MRI (Magnetic Resonance Imaging). Also useful for staining plaques and neurofibrillary tangles in brain tissue sections of Alzheimer's diseased patients with improved sensitivity, and reduced background.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number760988-03-2
      Chemical formulaC₂₄H₁₇FO₆
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (200 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesHiguchi, M., et al. 2005. Nat. Neurosci. 8, 527.
      Sato, K., et al. 2004. Eur. J. Med. Chem. 39, 573.