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324414 Dynamin Inhibitor V, 34-2 - CAS 1128165-88-7 - Calbiochem

The Dynamin Inhibitor V, 34-2 controls the biological activity of Dynamin. This small molecule/inhibitor is primarily used for Membrane applications.

Dynamin Inhibitor V, 34-2 - CAS 1128165-88-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-Cyano-N-octyl-3-(1-(3-dimethylaminopropyl)-1H-indol-3-yl)-acrylamide

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324414
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1128165-88-7C₂₅H₃₆N₄O

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324414-10MGCN
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      Description
      OverviewA cell-permeable, allosteric Dynamin inhibitor (IC50 = 6.9 µM and 14 µM for full length Dynamin I and Dynamin II GTPase activity, respectively, in vitro). 10 µM of this compound results in cytokinesis failure at the abscission stage in HeLa cultures, with 82% of cells that enter into mitosis becoming multinucleated, and with 97% resulting in cell death. However, it displays a much reduced effect in NIH3T3 cells at the same concentration. It elicits a dose-dependent reduction in cell growth against SMA-560, SJ-G2, SW480, MCF-7 and A2780 cultures, as being the most sensitive among a panel of other cancer cell lines (GI50 = 4.0–37 µM). It was further shown to be 6-fold more active (IC50 = 5.0 µM) than dynamin mediated receptor mediated endocytosis (RME) in U2OS cells, and 15-fold more active (IC50 = 1.3 µM) than Dynasore (Cat. No. 324410) in another Dynamin I GTPase activity assay.
      Catalogue Number324414
      Brand Family Calbiochem®
      Synonyms2-Cyano-N-octyl-3-(1-(3-dimethylaminopropyl)-1H-indol-3-yl)-acrylamide
      References
      ReferencesChircop, M. et al. 2011. Mol. Cancer Ther. 10, 1553.
      Hill, T.A., et al. 2009. J. Med. Chem. 52, 3762.
      Product Information
      CAS number1128165-88-7
      FormYellow solid
      Hill FormulaC₂₅H₃₆N₄O
      Chemical formulaC₂₅H₃₆N₄O
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      324414-10MGCN 04055977197204

      Documentation

      Dynamin Inhibitor V, 34-2 - CAS 1128165-88-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Dynamin Inhibitor V, 34-2 - CAS 1128165-88-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      324414

      References

      Reference overview
      Chircop, M. et al. 2011. Mol. Cancer Ther. 10, 1553.
      Hill, T.A., et al. 2009. J. Med. Chem. 52, 3762.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-June-2012 JSW
      Synonyms2-Cyano-N-octyl-3-(1-(3-dimethylaminopropyl)-1H-indol-3-yl)-acrylamide
      DescriptionA cell-permeable, allosteric Dynamin inhibitor (IC50 = 6.9 µM and 14 µM for full length Dynamin I and Dynamin II GTPase activity, respectively, in vitro). 10 µM of this compound results in cytokinesis failure at the abscission stage in HeLa cultures, with 82% of cells that enter into mitosis becoming multinucleated, and with 97% resulting in cell death. However, it displays a much reduced effect in NIH3T3 cells at the same concentration. It elicits a dose-dependent reduction in cell growth against SMA-560, SJ-G2, SW480, MCF-7 and A2780 cultures, as being the most sensitive among a panel of other cancer cell lines (GI50 = 4.0–37 µM). It was further shown to be 6-fold more active (IC50 = 5.0 µM) than dynamin mediated receptor mediated endocytosis (RME) in U2OS cells, and 15-fold more active (IC50 = 1.3 µM) than Dynasore (Cat. No. 324410) in another Dynamin I GTPase activity assay.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1128165-88-7
      Chemical formulaC₂₅H₃₆N₄O
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (100 mg/ml; clear, yellow solution)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesChircop, M. et al. 2011. Mol. Cancer Ther. 10, 1553.
      Hill, T.A., et al. 2009. J. Med. Chem. 52, 3762.