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259545 Deoxyhypusine Synthase Inhibitor, GC7 - CAS 150333-69-0 - Calbiochem

The Deoxyhypusine Synthase Inhibitor, GC7, also referenced under CAS 150333-69-0, controls the biological activity of Deoxyhypusine Synthase.

Deoxyhypusine Synthase Inhibitor, GC7 - CAS 150333-69-0 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N1-guanyl-1,7-diamine-heptane, 1-(7-ammonioheptyl)guanidinium sulfate

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259545
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
150333-69-0C₈H₂₂N₄O₄S

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      Description
      OverviewA cell-permeable inhibitor that targets the spermidine-binding site of Deoxyhypusine Synthase (Ki = 9.7 nM), an enzyme which is responsible for the first step hypunisation of eukaryotic initiation factor 5A (eIF5A). In vivo, it demonstrates almost complete cessation of hypusine formation in CHO cells at ≥ 1 µM. Several studies indicate this compound as a useful tool for the down-regulation of eIF5A, a protein essential for cell proliferation. For example, it exhibits an anti-proliferative effect on both BCR-ABL -positive and -negative leukemia cell lines (K562 and HL-60) dose-dependently, at concentrations between 5 µM and 40 µM. In addition, it is shown to significantly impair the growth and invasion of primary HCC cells (HepG2 and Hep3B) in the 10-20 µM range, and against non-tumorigenic CL-48 cells at concentrations as high as 40 µM, with no apparent cytotoxicity. At 25 µM, GC7 treatment is shown to reverse eIF5a-mediated Skeletal Muscle Stem Cell Differentiation.
      Catalogue Number259545
      Brand Family Calbiochem®
      SynonymsN1-guanyl-1,7-diamine-heptane, 1-(7-ammonioheptyl)guanidinium sulfate
      References
      ReferencesLee, N.P., et al. 2010. Int J Cancer. 4, 968.
      Luchessi, A., et al. 2008. J Cell Physiol. 3, 480.
      Balabanov, S., et al. 2007. Blood. 4, 1701.
      Jakus, J., et al. 1993. J Biol Chem. 18, 13151.
      Product Information
      CAS number150333-69-0
      FormWhite powder
      Hill FormulaC₈H₂₂N₄O₄S
      Chemical formulaC₈H₂₂N₄O₄S
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity>95% by NMR
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      259545-10MGCN 04055977217421

      Documentation

      Deoxyhypusine Synthase Inhibitor, GC7 - CAS 150333-69-0 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Deoxyhypusine Synthase Inhibitor, GC7 - CAS 150333-69-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      259545

      References

      Reference overview
      Lee, N.P., et al. 2010. Int J Cancer. 4, 968.
      Luchessi, A., et al. 2008. J Cell Physiol. 3, 480.
      Balabanov, S., et al. 2007. Blood. 4, 1701.
      Jakus, J., et al. 1993. J Biol Chem. 18, 13151.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision14-May-2012 JSW
      SynonymsN1-guanyl-1,7-diamine-heptane, 1-(7-ammonioheptyl)guanidinium sulfate
      DescriptionA cell-permeable inhibitor that targets the spermidine-binding site of Deoxyhypusine Synthase (Ki = 9.7 nM), an enzyme which is responsible for the first step hypunisation of eukaryotic initiation factor 5A (eIF5A). In vivo, it demonstrates almost complete cessation of hypusine formation in CHO cells at ≥ 1 µM. Several studies indicate this compound as a useful tool for the down-regulation of eIF5A, a protein essential for cell proliferation. For example, it exhibits an anti-proliferative effect on both BCR-ABL -positive and -negative leukemia cell lines (K562 and HL-60) dose-dependently, at concentrations between 5 µM and 40 µM. In addition, it is shown to significantly impair the growth and invasion of primary HCC cells (HepG2 and Hep3B) in the 10-20 µM range, and against non-tumorigenic CL-48 cells at concentrations as high as 40 µM, with no apparent cytotoxicity. At 25 µM, GC7 treatment is shown to reverse eIF5a-mediated Skeletal Muscle Stem Cell Differentiation.
      FormWhite powder
      CAS number150333-69-0
      Chemical formulaC₈H₂₂N₄O₄S
      Structure formulaStructure formula
      Purity>95% by NMR
      SolubilityH₂O (25 mg/ml; clear, colorless solution)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesLee, N.P., et al. 2010. Int J Cancer. 4, 968.
      Luchessi, A., et al. 2008. J Cell Physiol. 3, 480.
      Balabanov, S., et al. 2007. Blood. 4, 1701.
      Jakus, J., et al. 1993. J Biol Chem. 18, 13151.