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Merck

204897

Complement C4b, Human

Complement C4b, Human, is a native, 193 kDa glycoprotein composed of the modified C4 α-chain (α′) and intact β- and γ-chains complement component.

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About This Item

NACRES:
NA.25
UNSPSC Code:
12352202

Key Documents

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Product Name

Complement C4b, Human, Complement C4b, Human, is a native, 193 kDa glycoprotein composed of the modified C4 α-chain (α′) and intact β- and γ-chains complement component.

assay

≥95% (SDS-PAGE)

form

liquid

does not contain

preservative

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
avoid repeated freeze/thaw cycles

impurities

IgG, IgA, IgM, Factor B, Factor H, C3, ceruloplasmin, or albumin, trace

shipped in

wet ice

storage temp.

−70°C

Quality Level

100

Biochem/physiol Actions

Complement C4b fragment is formed by the cleavage of the C4 α-chain by activated C1 enzyme. Like C3b, C4b has the transient ability to form a covalent ester bond with a variety of target cell surfaces. Target surface-bound C4b acts as an important non-enzymatic subunit of the classical pathway C3 cleaving enzyme (C4b, C2a). This surface-bound C4b also exhibits opsonic and immune adherence activities which are dependent on the CR1 (CD35) complement receptor found on many inflammatory cells.
ComplementC4b fragment is formed by the cleavage of the C4 α-chain by activated C1enzyme. Like C3b, C4b has the transient ability to form a covalent ester bond with a variety of target cell surfaces. Target surface-bound C4b acts as an important non-enzymatic subunit of the classical pathway C3 cleaving enzyme (C4b, C2a). This surface-bound C4b also exhibits opsonic and immune adherence activities which are dependent on the CR1 (CD35) complement receptor found on many inflammatory cells.

Disclaimer

Toxicity: Standard Handling (A)

Packaging

Please refer to vial label for lot-specific concentration.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Global Trade Item Number

SKUGTIN
204897-250UGCN04055977219852

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