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500112 Cocarboxylase chloride

(thiamine diphosphoric acid ester chloride) EMPROVE® API

Cocarboxylase chloride MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Thiaminium diphosphoric acid ester chloride, Thiaminium pyrophosphate chloride, Thiaminium pyrophosphoric acid ester chloride, TPP

CAS #: 154-87-0 EC Number: 205-836-1 Molar Mass: 460.80 g/mol Hill Formula: C₁₂H₁₉ClN₄O₇P₂S
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500112
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Key Spec Table

CAS #EC NumberHill FormulaMolar Mass
154-87-0205-836-1C₁₂H₁₉ClN₄O₇P₂S460.80 g/mol

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          Description
          Catalogue Number500112
          SynonymsThiaminium diphosphoric acid ester chloride, Thiaminium pyrophosphate chloride, Thiaminium pyrophosphoric acid ester chloride, TPP
          References
          Product Information
          CAS number154-87-0
          EC number205-836-1
          Hill FormulaC₁₂H₁₉ClN₄O₇P₂S
          Molar Mass460.80 g/mol
          HS Code2936 22 90
          Structure formula ImageStructure formula Image
          Quality LevelMQ600
          Applications
          Biological Information
          Physicochemical Information
          Melting Point240 - 244 °C (decomposition)
          pH value2.2 (H₂O)
          Bulk density500 kg/m3
          Solubility220 g/l
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Hazard Pictogram(s) Hazard Pictogram(s)
          Hazard Statement(s)H317: May cause an allergic skin reaction.
          Precautionary Statement(s)P261: Avoid breathing dust.
          P272: Contaminated work clothing should not be allowed out of the workplace.
          P280: Wear protective gloves.
          P302 + P352: IF ON SKIN: Wash with plenty of water.
          P333 + P313: If skin irritation or rash occurs: Get medical advice/ attention.
          P362 + P364: Take off contaminated clothing and wash it before reuse.
          Signal WordWarning
          RTECSXI7552000
          Storage class10 - 13 Other liquids and solids
          WGKWGK 1 slightly hazardous to water
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          StorageStore at +2°C to +25°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Assay (HPLC, calc. on dried substance)≥ 93.0 %
          Appearance (color)white
          Appearance (description)crystalline powder
          Identity (IR-spectrum)conforms
          Identity (Cl)passes test
          Appearance of solution (10 %; water)clear,< colour reference solution Y7
          pH-value (10 %; water)1.0 - 1.4
          Chloride (Cl) (calculated on dried substance)7.5 - 7.9 %
          Free phosphate (PO₄)≤ 1.0 %
          Sulfate (SO₄)≤ 0.01 %
          Al (Aluminium) (#)≤ 0.0010 %
          As (Arsenic)≤ 0.0003 %
          Ni (Nickel) (#)≤ 0.0002 %
          Thiamin Monophosphoric Acid Ester Chloride (HPLC)≤ 4.0 %
          Thiamin Dichloride (HPLC)≤ 0.5 %
          Dithiamine Triphosphate (HPLC)≤ 0.20 %
          Impurity A (HPLC)≤ 0.1
          Impurity B (HPLC)≤ 0.1
          Related substances (HPLC)≤ 1.5 %
          Loss on drying (130 °C)≤ 1.5 %
          Endotoxins≤ 12 I.U./g
          Microbiological testpasses test
          Colony count (aerobic bacteria (TAMC))≤ 500 CFU/g
          Colony count (Yeasts and moulds (TYMC))≤ 100 CFU/g
          Salmonella speciesIn 10g substance not detectable
          E.coliIn 1g substance not detectable
          Staphylococcus aureusIn 1g substance not detectable
          Pseudomonas aeruginosaIn 1g substance not detectable
          Candida albicansIn 1g substance not detectable
          Residual solvents (Ph Eur/USP/ICH) class 2 (Methanol)≤ 2.0 %
          Other residual solvents (Ph Eur/USP/ICH)excluded by manufacturing process
          Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities).
          Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (#).
          Residues of metal or metal reagents acc. to EMEA/CHMP/SWP/ 4446/2000 are not likely to be present.
          Global Trade Item Number
          Catalogue Number GTIN
          5.00112.1000 04022536255934
          5.00112.5000 04022536255972

          Documentation

          Emprove® API Information Package

          Title

          Cocarboxylase chloride SDS

          Title

          Safety Data Sheet (SDS) 

          Cocarboxylase chloride Certificates of Analysis

          Product Number PackagingSpecificationLot Number
          5.00112.1000 Plastic bottlePDF Specification Document
          5.00112.5000 Plastic bottlePDF Specification Document

          Certificates

          Title