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AB15242 Anti-zDHHC8 Antibody

Anti-zDHHC8 Antibody is an antibody against zDHHC8 for use in WB.

Anti-zDHHC8 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience Gene Symbol: DHHC-8, EC 2.3.1.- , KIAA1292, ZDHHCL1, ZNF378 UniProt Number: Q9ULC8
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AB15242
100 µg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, RWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB15242
      DescriptionAnti-zDHHC8 Antibody
      Alternate Names
      • Zinc finger DHHC domain-containing protein 8
      • Zinc finger protein 378
      • membrane-associated DHHC8 zinc finger protein
      • zinc finger, DHHC domain containing 8
      • zinc finger, DHHC domain like containing 1
      • zinc finger, DHHC-type containing 8
      Background InformationSix genes in the 1.5 Mb region of chromosome 22 deleted in DiGeorge/22q11 deletion syndrome–Mrpl40, Prodh, Slc25a1, Txnrd2, T10, and Zdhhc8–encode mitochondrial proteins. All six genes are expressed in the
      brain, and maximal expression coincides with peak forebrain synaptogenesis shortly after birth. Furthermore, their protein products are associated with brain mitochondria, including those in synaptic terminals. Among the six, only Zddhc8 influences mitochondria-regulated apoptosis when overexpressed, and appears to interact biochemically with established mitochondrial proteins. Zdhhc8 has an apparent interaction with Uqcrc1, a component of mitochondrial complex III. The two proteins are coincidently expressed in pre-synaptic processes; however, Zdhhc8 is more frequently seen in glutamatergic terminals (1).
      References
      Product Information
      FormatAffinity Purified
      Control
      • Fetal human brain
      PresentationPurified in PBS with 0.05% NaN3
      Quality LevelMQ100
      Applications
      ApplicationAnti-zDHHC8 Antibody is an antibody against zDHHC8 for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenSyntheic linear peptide.
      EpitopeC-Terminus
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityCat. AB15242 recognizes the C-terminus of zDHHC8.
      Species Reactivity
      • Human
      • Rat
      Species Reactivity NoteHuman and Rat. Predicted to react with horse, pig, opposum, mouse, cow, xenopus, chimp ,chicken, dog, ape.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • DHHC-8
      • EC 2.3.1.-
      • KIAA1292
      • ZDHHCL1
      • ZNF378
      Purification MethodImmunoAffinity Purified
      UniProt Number
      UniProt SummaryFUNCTION: Putative palmitoyltransferase involved in glutamatergic transmission By similarity.

      Catalytic activity Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA.

      SUBCELLULAR:Cytoplasmic vesicle membrane; Multi-pass membrane proteinPotential.

      DOMAIN: The DHHC domain is required for palmitoyltransferase activity By similarity.

      DISEASE: According to Ref.6 and Ref.7, defects in ZDHHC8 may contribute to susceptibility to schizophrenia, but according to Ref.8, Ref.9 and Ref.10, it is not the case.

      SIMILARITY: Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.

      Contains 1 DHHC-type zinc finger.
      Molecular Weight~71 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by western blot in fetal human brain lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Handling Recommendations: Prior to removing the cap, gently centrifuge the vial and gently mix the solution.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB15242 04053252404573