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AB10556 Anti-mGluR8 Antibody

Anti-mGluR8 Antibody detects level of mGluR8 & has been published & validated for use in IH.

Anti-mGluR8 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neurotransmitters & Receptors Gene Symbol: GLUR8, mGlu8, GPRC1H, MGLUR8, FLJ41058, MGC126724, GRM8 UniProt Number: O00222
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AB10556
100 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      RIHCGpSerumPolyclonal Antibody
      Description
      Catalogue NumberAB10556
      DescriptionAnti-mGluR8 Antibody
      Alternate Names
      • glutamate metabotropic receptor 8
      • glutamate receptor
      • metabotropic 8
      Background InformationL-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
      References
      Product Information
      FormatSerum
      Control
      • Rat brain lysate
      PresentationUnpurified guinea pig polyclonal serum with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-mGluR8 Antibody detects level of mGluR8 & has been published & validated for use in IH.
      Key Applications
      • Immunohistochemistry
      Application NotesEvaluated by Western Blot in rat brain lysate. Although intended for use in IHC analysis, a band was observed at ~101kDa.
      Biological Information
      ImmunogenThis antibody is generated from guinea pigs immunized with a KLH-conjugated linear peptide selected from residues corresponding to the cytoplasmic domain of rat mGluR8.
      EpitopeCytoplasmic Domain
      HostGuinea Pig
      SpecificityThis antibody recognizes mGluR8.
      Species Reactivity
      • Rat
      Species Reactivity NotePredicted to react with human, chimpanzee, monkey, dog, cow and mouse based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryL-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene
      Gene Symbol
      • GLUR8
      • mGlu8
      • GPRC1H
      • MGLUR8
      • FLJ41058
      • MGC126724
      • GRM8
      Purification MethodUnpurified
      UniProt Number
      UniProt SummaryFUNCTION: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity.

      SUBUNIT STRUCTURE: Interacts with PICK1 By similarity.

      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.

      SEQUENCE SIMILARITIES: Belongs to the G-protein coupled receptor 3 family.
      Molecular Weight101 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceImmunohistochemistry Analysis: : 1:100-500 dilution from a previous lot detected mGluR8 on rat brain tissue.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB10556 04053252370533