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AB2265 Anti-VPAC1 Antibody

Anti-VPAC1 Antibody detects level of VPAC1 & has been published & validated for use in IH(P) & WB.

Anti-VPAC1 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Hormones & Receptors Gene Symbol: VIPR1, PACAP-R-2, RCD1, VIP-R-1, VPAC1, VIRG, HVR1, VPCAP1R, VAPC1, VIPR, RDC1 UniProt Number: P97751
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AB2265
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RIH(P), WBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB2265
      DescriptionAnti-VPAC1 Antibody
      Alternate Names
      • Vasoactive intestinal polypeptide receptor 1
      • Pituitary adenylate cyclase-activating polypeptide type II receptor
      • vasoactive intestinal peptide/pituitary adenylate cyclase activating peptide receptor 1
      Background InformationThe vasoactive intestinal peptide/pituitary adenylate cyclase activating peptide receptor 1 (VPAC1) is a member of a class II subfamily of G-protein-coupled receptors and has a high affinity for vasoactive intestinal peptide (VIP). VPAC1 has been associated with many different lung cancer cell lines. VPAC1 is thought to be activated by FXR and may contribute to the regulation of bile secretion to protect against gallstone disease. VPAC1 could be used to regulate VIPs and, in turn, inhibit breast cancer growth. VPAC1 has also been implicated in regulation of the anti-inflammatory effects of VIP.
      References
      Product Information
      FormatAffinity Purified
      Control
      • SK-OV-3 cell lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-VPAC1 Antibody detects level of VPAC1 & has been published & validated for use in IH(P) & WB.
      Key Applications
      • Immunohistochemistry (Paraffin)
      • Western Blotting
      Application NotesImmunohistochemistry Analysis: 1:500 dilution from a previous lot detected VPAC1 in ovarian carcinoma tissue.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the cytoplasmic domain of VPAC1.
      EpitopeCytoplasmic domain
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes VPAC1 at the cytoplasmic domain.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • VIPR1
      • PACAP-R-2
      • RCD1
      • VIP-R-1
      • VPAC1
      • VIRG
      • HVR1
      • VPCAP1R
      • VAPC1
      • VIPR
      • RDC1
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.

      SEQUENCE SIMILARITIES: Belongs to the G-protein coupled receptor 2 family.
      Molecular Weight~52 kDa observed. Multiple molecular weights of VPAC1 may be due to glycosylation. (Fabre, C, et al. (1993). Peptides. 14:483-489.)
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in SK-OV-3 cell lysate.

      Western Blot Analysis: 1 µg/mL of this antibody detected VPAC1 on 10 µg of SK-OV-3 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB2265 04053252415692