Millipore Sigma Vibrant Logo

AB15570-I Anti-Tryptophan hydroxylase 1/TPH1 Antibody

This Anti-Tryptophan hydroxylase 1/TPH1 antibody is validated for use in western blotting & IHC (Paraffin) for the detection of Tryptophan hydroxylase 1/TPH1.

Anti-Tryptophan hydroxylase 1/TPH1 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Signaling Gene Symbol: Tph1, Tph UniProt Number: P09810
View This Product on Sigma-Aldrich
AB15570-I
100 µg  
Retrieving price...
Price could not be retrieved
Minimum Quantity is a multiple of
Maximum Quantity is
Upon Order Completion More Information
You Saved ()
 
—
Request Pricing
—
Limited Availability Limited Availability
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      Special Offers

       

      Contact Customer Service

      Overview

      Replacement Information

      Special Offers

      100% Performance Guaranteed

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MWB, IH(P)RbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB15570-I
      ReplacesAB15570
      DescriptionAnti-Tryptophan hydroxylase 1/TPH1 Antibody
      Alternate Names
      • Tryptophan 5-hydroxylase 1
      • Tryptophan 5-monooxygenase 1
      Background InformationTryptophan hydroxylase 1/TPH1, also known as Tryptophan 5-hydroxylase 1, also known as Tryptophan 5-monooxygenase 1, and encoded by the gene TPH1/TPH/TPRH/TRPH, is an important biosynthetic enzyme needed for serotonin synthesis from L-trytophan. TPH1 is responsible for the addition of the -OH grouip to 5-hydroxytryptophan which is the initial and rate limiting step in the synthesis of serotonin. Serotonin in a neurotransmitter and has an antidepressant effect on the brain. The activity of TPH1 is also modulated by phosphorylation Protein Kinase A is responsible for the phosphorylation of TPH1 and helps to modulate its activity in neurons. TPH1 is mostly expressed in tissues that express serotonin such as the brain, pineal gland, and CNS but also can be found in skin and intestinal tissues.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Tryptophan hydroxylase 1/TPH1 antibody is validated for use in western blotting & IHC (Paraffin) for the detection of Tryptophan hydroxylase 1/TPH1.
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: A 1:50-500 dilution from a representative lot detected Tryptophan hydroxylase 1/TPH1 in mouse pancreas and mouse colon tissue.
      Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Tryptophan hydroxylase 1/TPH1 in mouse cerebellum and mouse cerebral cortex tissue.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the C-terminus of rat Tryptophan hydroxylase 1/TPH1.
      EpitopeC-terminus
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Mouse
      Species Reactivity NoteMouse. Predicted to react with Rat based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Tph1
      • Tph
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~51 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in P815 cell lysate.

      Western Blotting Analysis: 2.0 µg/mL of this antibody detected Tryptophan hydroxylase 1/TPH1 in 10 µg of P815 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB15570-I 04053252961069

      Documentation

      Anti-Tryptophan hydroxylase 1/TPH1 Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Tryptophan hydroxylase 1/TPH1 Antibody Certificates of Analysis

      TitleLot Number
      Anti-Tryptophan hydroxylase 1/TPH1 - Q2388158 Q2388158
      Anti-Tryptophan hydroxylase 1/TPH1 - 3227307 3227307
      Anti-Tryptophan hydroxylase 1/TPH1 - 3742323 3742323
      Anti-Tryptophan hydroxylase 1/TPH1 - 3928041 3928041
      Anti-Tryptophan hydroxylase 1/TPH1 - 4163456 4163456
      Anti-Tryptophan hydroxylase 1/TPH1 -2659586 2659586
      Anti-Tryptophan hydroxylase 1/TPH1 -2700258 2700258
      Anti-Tryptophan hydroxylase 1/TPH1 -2753824 2753824
      Anti-Tryptophan hydroxylase 1/TPH1 Polyclonal Antibody 2953851
      Anti-Tryptophan hydroxylase 1/TPH1 Polyclonal Antibody 3089573