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MABN839 Anti-TrpV6 Antibody, clone 4A5.1

Anti-TrpV6 Antibody, clone 4A5.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience Gene Symbol: TRPV6, ABP/ZF, CAT1, CATL, ECAC2, ZFAB UniProt Number: Q9H1D0
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MABN839
100 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWB, IHCMCulture SupernatantMonoclonal Antibody
      Description
      Catalogue NumberMABN839
      DescriptionAnti-TrpV6 Antibody, clone 4A5.1
      Alternate Names
      • Transient receptor potential cation channel subfamily V member 6
      • Alu-binding protein with zinc finger domain
      • Calcium transport protein 1, Calcium transporter-like protein
      • CaT-L
      • CaT-like
      • CaT1
      • ECaC2
      • Epithelial apical membrane calcium transporter/channel CaT1
      • Epithelial calcium channel 2
      • TrpV6
      Background InformationTransient receptor potential cation channel subfamily V member 6 (UniProt Q9H1D0; also known as Alu-binding protein with zinc finger domain, Calcium transport protein 1, Calcium transporter-like protein, CaT-L, CaT-like, CaT1, ECaC2, Epithelial apical membrane calcium transporter/channel CaT1, Epithelial calcium channel 2, TrpV6) is encoded by the TRPV6 (also known as ABP/ZF, CAT1, CATL, ECAC2, ZFAB) gene (Gene ID 55503) in human. TRPV6 belongs to the transient receptor potential (TRP) family of membrane proteins. The human TRPV6 is an 765-amino acid, six-transmembrane protein with both N- and C-termini exposed intracellularly. TRPV6 contains a pore-forming loop domain located between the fifth and sixth transmembrane region. Among all the TRPV family members, TRPV5 and TRPV6 are the two highly Ca2+-selective channels that play pivotal roles in the Ca2+-reabsorption in the kidney and intestine, respectively. TRPV6 is found in the apical brush-border membrane of the intestinal enterocytes where it regulates calcium entry into the cells. TRPV6 expression is also reported in human placenta, pancreas, and prostate gland. Vitamin D treatment of human colon cancer Caco-2 cells and duodenal explants results in upregulated TRPV6 mRNA levels.
      References
      Product Information
      FormatCulture Supernatant
      PresentationIn culture supernatant without preservatives.
      Quality LevelMQ100
      Applications
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesWestern Blotting Analysis: A 1:500 dilution from a representative lot detected TrpV6 in 10 µg of LNCaP prostate adenocarcinoma and K562 erythroleukemia cell lysates.
      Immunohistochemistry Analysis: A 1:50-1:250 dilution from a representative lot detected TrpV6 in human pancreas, human small intestine, rat colon tissue, and mouse brain tissues.
      Biological Information
      ImmunogenGST-tagged recombinant human TrpV6 C-terminal fragment.
      EpitopeC-terminal region.
      Clone4A5.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityExpected to react with both spliced isoforms of human TrpV6 reported by UniProt (Q9H1D0).
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • TRPV6
      • ABP/ZF
      • CAT1
      • CATL
      • ECAC2
      • ZFAB
      Purification MethodUnpurified
      UniProt Number
      Molecular Weight~70 kDa observed.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in Y79 retinoblastoma cell lysate.

      Western Blotting Analysis: A 1:500 dilution of this antibody detected TrpV6 in 10 µg of Y79 retinoblastoma cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABN839 04055977311839

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies