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AB19011 Anti-Tenascin Antibody

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AB19011
50 µg  
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      Overview

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWB, IH(P)RbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB19011
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Tenascin Antibody
      Alternate Names
      • Tenascin C
      Background InformationTenascin is known to play an active role in development of central nervous system and mesenchymal-derived organs, exist in the vasculature of tumors in adults, and function in cell adhesion.
      Product Information
      FormatAffinity Purified
      HS Code3002 15 90
      PresentationAffinity purified using immobilized human tenascin; presented as a liquid in PBS containing no preservatives.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Tenascin Antibody is validated for use in WB, IH(P) for the detection of Tenascin.
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesWestern blot: 0.5 - 1.0 μg/mL; recognizes 250-350 kDa polypeptides in reduced samples.
      Immunohistochemistry: 10 to 20 μg/mL in paraffin embedded tissues

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenPurified human tenascin from glioma culture supernatant.
      HostRabbit
      SpecificityReacts strongly with tenascin from human and mouse in both Western blotting and immunohistochemistry. While it has not been tested, it should also react strongly in these applications with tenascin from all mammalian species.
      Species Reactivity
      • Human
      • Mouse
      Species Reactivity NoteReactivity with other species has not been confirmed, but likely to react with all mammalian species.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • TNC
      • Hexabrachion
      • HXB
      • GMEM
      • TN
      • Neuronectin
      • Tenascin-C
      • MGC167029
      • JI
      • TN-C
      • Cytotactin
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P24821 # Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6.
      SIZE: 2201 amino acids; 240866 Da
      SUBUNIT: Homohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the central globule. Interacts with CSPG4.
      SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
      PTM: N-glycosylated (By similarity).
      SIMILARITY: SwissProt: P24821 ## Belongs to the tenascin family. & Contains 15 EGF-like domains. & Contains 1 fibrinogen C-terminal domain. & Contains 15 fibronectin type-III domains.
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C for up to 12 months from date of receipt. Aliquot to avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size50 µg
      Global Trade Item Number
      Catalogue Number GTIN
      AB19011 04053252328237