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ABC926 Anti-TRIM11 Antibody

Detect TRIM11 using this rabbit polyclonal Anti-TRIM11 Antibody, Cat. No. ABC926, validated for use in Western Blotting and Immunohistochemistry (Paraffin).

Anti-TRIM11 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: TRIM11, RNF92 UniProt Number: Q96F44
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ABC926
100 μg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWB, IH(P)RbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABC926
      DescriptionAnti-TRIM11 Antibody
      Alternate Names
      • E3 ubiquitin-protein ligase TRIM11
      • Protein BIA1
      • RING finger protein 92
      • Tripartite motif-containing protein 11
      • TRIM11
      Background InformationE3 ubiquitin-protein ligase TRIM11 (UniProt Q96F44; also known as Protein BIA1, RING finger protein 92, Tripartite motif-containing 11, Tripartite motif-containing protein 11) is encoded by the TRIM11 (also known as BIA1, RNF92) gene (Gene ID 81559) in human. TRIM11 belongs to a family of more than 70 TRIM/RBCC proteins characterized by their shared tripartite motif structure, also known as the RBCC (RING finger, B-box, and coiled-coil) domain. The B-box and coiled coil regions are believed to participate in protein-protein interactions and formation of macromolecular complexes. TRIM proteins are involved in diverse cellular processes, including cell proliferation, differentiation, oncogenesis, and apoptosis. The presence of a RING domain suggests that TRIM proteins function as E3 ubiquitin ligases. The neuroprotective peptide humanin, activator-recruited cofactor (ARC) 105-kDa component (ARC105), the transcription factors Pax6 and PHOX2B are all known subrates targeted by TRIM11-mediated degradation through the ubiquitin-proteasome system. In addition, TRIM11 is also reported to interfere with the early steps of HIV-1 replication in host cells in a RING domain-dependent manner.
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect TRIM11 using this rabbit polyclonal Anti-TRIM11 Antibody, Cat. No. ABC926, validated for use in Western Blotting and Immunohistochemistry (Paraffin).
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: A 1:50-250 dilution from a representative lot detected TRIM11 in human prostate cancer, human colon cancer, human melanoma, and human kidney tissue.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human TRIM11.
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityThis antibody is expected to react with all three spliced isoforms of human TRIM11.
      Species Reactivity
      • Human
      • Mouse
      Species Reactivity NoteHuman, Mouse. Predicted to react with Rhesus Macaque, Canine based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • TRIM11
      • RNF92
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~53 kDa observed. 52.8 kDa (isoform 1), 43.0 kDa (isoform 2), and 52.6 kDa (isoform 3) calculated.
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in murine macrophage RAW264.7 cell lysate.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected TRIM11 in 10 µg of murine macrophage RAW264.7 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Global Trade Item Number
      Catalogue Number GTIN
      ABC926 04055977176872