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MABN720 Anti-TBX1 Antibody, clone 7E12.1

Anti-TBX1 Antibody, clone 7E12.1 is an antibody against TBX1 for use in Western Blotting.

Anti-TBX1 Antibody, clone 7E12.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Transcription Factors Gene Symbol: TBX1, CTHM, DGS, TBX1C, VCFS UniProt Number: O43435
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MABN720
100 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWBMCulture SupernatantMonoclonal Antibody
      Description
      Catalogue NumberMABN720
      ReplacesAB15624
      DescriptionAnti-TBX1 Antibody, clone 7E12.1
      Alternate Names
      • T-box transcription factor TBX1
      • T-box protein 1
      • Testis-specific T-box protein
      Background InformationT-box transcription factor TBX1 (UniProt O43435; also known as T-box protein 1, Testis-specific T-box protein) is encoded by the TBX1 (also known as CTHM, DGS, TBX1C, VCFS) gene (Gene ID 6899) in human. TBX1 blongs to the T-box family of transcription factors that play important roles in the formation of tissues and organs during embryonic development. TBX1 is required for the second heart field (SHF) development for outflow tract development by regulating proliferation and differentiation of SHF cells. TBX1 is also shown to negatively regulate thymic epithelial cell (TEC) growth and differentiation in mice, extinction of Tbx1 gene expression in the third pharyngeal pouch (3rd pp) endoderm is a prerequisite for thymus organogenesis. Human TBX mutations cause DiGeorge syndrome, characterized by parathyroid hypoplasia, thymic hypoplasia, defects in the outflow tract of the heart, and craniofacial anomalies.
      References
      Product Information
      FormatCulture Supernatant
      PresentationMouse monoclonal IgG2aκ hybridoma culture supernatant without preservatives.
      Quality LevelMQ100
      Applications
      ApplicationAnti-TBX1 Antibody, clone 7E12.1 is an antibody against TBX1 for use in Western Blotting.
      Key Applications
      • Western Blotting
      Application NotesWestern Blotting Analysis: A 1:500 dilution from a representative lot detected TBX1 in 10 µg of mouse Neuro-2a and human SH-SY5Y neuroblastoma cell lysates.
      Biological Information
      ImmunogenGST-tagged recombinant human TBX1 C-terminal fragment.
      EpitopeC-terminal region.
      Clone7E12.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 7E12.1 was raised against a recombinant fragment derived from TBX1 spliced isoform A (Uniprot O43435-1), cross-reactivity toward spliced isoform B and isoform C (TBX1C) is possible, but has not been determined.
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • TBX1
      • CTHM
      • DGS
      • TBX1C
      • VCFS
      Purification MethodUnpurified
      UniProt Number
      Molecular Weight~48 kDa observed. 43.13 kDa (isoform A), 40.35 kDa (isoform B), and 52.67 kDa (isoform C; TBX1C) calculated. Uncharacterized band(s) may appear in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HUVEC lysate.

      Western Blotting Analysis: A 1:500 dilution of this antibody detected TBX1 in 10 µg of HUVEC lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABN720 04055977349641

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies