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MAB5618 Anti-Serotonin Transporter Antibody

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MAB5618
100 µL  
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      Overview

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, PmIHCMAscitesMonoclonal Antibody
      Description
      Catalogue NumberMAB5618
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Serotonin Transporter Antibody
      Alternate Names
      • SERT
      Product Information
      FormatAscites
      PresentationAscites
      Quality LevelMQ100
      Applications
      ApplicationAnti-Serotonin Transporter Antibody detects level of Serotonin Transporter & has been published & validated for use in IH.
      Key Applications
      • Immunohistochemistry
      Application NotesImmunohistochemistry: 1:500-1:1,000 on 10% formalin fixed, paraffin embedded tissue from human Medulla oblongata. Suggested antigen retrieval method is Heat Induced Epitope Retrieval (HIER): Citrate Buffer pH 6.0.

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenSynthetic peptide from human serotonin transporter.
      HostMouse
      SpecificitySerotonin Transporter, human and non-human primate.
      IsotypeIgG
      Species Reactivity
      • Human
      • Primate
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.
      Gene Symbol
      • SLC6A4
      • 5HTT
      • HTT
      • OCD1
      • hSERT
      • 5-HTT
      • SERT
      Non-Reactive Species
      • Rat
      Purification MethodAscites
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P31645 # Terminates the action of serotonin by its high affinity sodium-dependent reuptake into presynaptic terminals.
      SIZE: 630 amino acids; 70325 Da
      SUBUNIT: Interacts with TGFB1I1.
      SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
      SIMILARITY: SwissProt: P31645 ## Belongs to the sodium:neurotransmitter symporter (SNF) family.
      MISCELLANEOUS: This protein is the target of psychomotor stimulants such as amphetamines or cocaine.
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20degC in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µL
      Global Trade Item Number
      Catalogue Number GTIN
      MAB5618 04053252463600