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ABE2622 Anti-SYCP2

Anti-SYCP2 , Cat. No. ABE2622, is a highly specific rabbit polyclonal antibody that targets Synaptonemal complex protein 2 and has been tested in Immunofluorescence and Western Blotting.

Anti-SYCP2 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Gene Symbol: Sycp2, Scp2 UniProt Number: Q9CUU3
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ABE2622
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWB, IFRbSerumPolyclonal Antibody
      Description
      Catalogue NumberABE2622
      DescriptionAnti-SYCP2
      Alternate Names
      • Synaptonemal complex protein 2
      • SCP-2
      • Synaptonemal complex lateral element protein
      Background InformationSynaptonemal complex protein 2 (UniProt: Q9CUU3; also known as SCP-2, SYCP2, Synaptonemal complex lateral element protein) is encoded by the Sycp2 (also known as Scp2) gene (Gene ID: 320558) in murine species.SYCP2 is present in testis and spermatocyte and is a major component of the axial/lateral elements of synaptonemal complexes (SCS) during meiotic prophase and plays a role in the assembly of synaptonemal complexes. It is required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility. SYCP2 is considered to be a primary determinant of axial/lateral elements and can heterodimerize with SYCP3 and it is is required for the incorporation of SYCP3 into the synaptonemal complex. An evolutionarily conserved coiled coil domain in SYCP2 is required for binding to SYCP3. Defects in SYCP2 leads to sterility in male mice due to defective meiotic chromosome synapsis during spermatocyte development. Also, SYCP2 deficient mice show much reduced testes weight.
      References
      Product Information
      FormatSerum
      PresentationRabbit polyclonal anti-serum with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-SYCP2 , Cat. No. ABE2622, is a highly specific rabbit polyclonal antibody that targets Synaptonemal complex protein 2 and has been tested in Immunofluorescence and Western Blotting.
      Key Applications
      • Western Blotting
      • Immunofluorescence
      Application NotesImmunofluorescence Analysis: A representative lot detected SYCP2 in spread nuclei of mouse spermatocytes. (Courtesy of Dr. P. Jeremy Wang at University of Pennsylvania).

      Immunofluorescence Analysis: A representative lot detected SYCP2 in spread nuclei of oocytes and spermocytes (Yang, F., et. al. (2015). EMBO Mol Med. 7(9):1198-210).

      Western Blotting Analysis: A representative lot detected SYCP2 in adult mouse testis tissue lysate (Yang, F., et. al. (2006). J Cell Biol. 173(4):497-507).
      Biological Information
      ImmunogenHis-tagged recombinant fragment corresponding to 246 amino acids from the C-terminal region of murine Synaptonemal complex protein 2.
      EpitopeC-terminus
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityThis polyclonal antibody detects Synaptonemal complex protein 2 in mouse testis and recognizes an epitope within amino acids 1255-1500 in the C-terminal region.
      Species Reactivity
      • Human
      • Mouse
      Species Reactivity NoteHuman, Mouse.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Sycp2
      • Scp2
      Purification MethodUnpurified
      UniProt Number
      Molecular Weight~200 kDa observed; 172.12 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in mouse testis tissue lysate.

      Western Blotting Analysis: A 1:1,000 dilution of this antibody detected SYCP2 in 50 µg of mouse testis tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.

      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABE2622 04054839169618