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16-321 Anti-Ras Magnetic Bead Conjugate Antibody

Anti-Ras Magnetic Bead Conjugate Antibody detects level of Ras Magnetic Bead Conjugate & has been published & validated for use in WB & IP.

Anti-Ras Magnetic Bead Conjugate Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: MAP Kinases, G-proteins Gene Symbol: K-Ras, Ki-Ras, K-Ras2, Kras-2, p21B, KRAS, RASK2, HRAS, HA_RAS, N-RAS, H-RAS, NRAS, NRAS1, ALPS4 UniProt Number: P01116
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16-321
200 µL  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, R, MWB, IPMPurifiedMonoclonal Antibody
      Description
      Catalogue Number16-321
      DescriptionAnti-Ras Magnetic Bead Conjugate Antibody
      Alternate Names
      • GTP- and GDP-binding peptide B
      • GTPase Hras
      • Ha-Ras1 proto-oncoprotein
      • Ras family small GTP binding protein H-Ras
      • Transforming protein p2
      • c-has/bas p21 protein
      • c-ras-Ki-2 activated oncogene
      • p19 H-RasIDX protein
      • transformation gene: oncogene HAMSV
      • v-Ha-ras Harvey rat sarcoma viral oncogene homolog
      Background InformationThe tumor oncoproteins HRas, KRas, and NRas are rated as Ras protoncogenes. Point mutations within Ras genes are frequently detected in human malignancies and in experimentally induced tumors in animals.
      References
      Product Information
      FormatPurified
      Control
      • A431 whole cell lysate
      Presentation20% slurry; 1xPBS, 0.05% sodium azide. Sufficient for 10 immunoprecipitation assays.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Ras Magnetic Bead Conjugate Antibody detects level of Ras Magnetic Bead Conjugate & has been published & validated for use in WB & IP.
      Key Applications
      • Western Blotting
      • Immunoprecipitation
      Application NotesImmunoprecipitation:
      150 μg of this antibody has been reported to immunoprecipitate Ras.
      Biological Information
      ImmunogenKLH-conjugated protein corresponding to human Ras.
      HostMouse
      SpecificityThis antibody recognizes p21H-, K- and N-Ras.
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      • Rat
      • Mouse
      Species Reactivity NoteProven to react with human, mouse and rat. Other species unknown.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryMembers of the RAS superfamily of GTP-binding proteins, which includes MRAS, are membrane-anchored, intracellular signal transducers responsible for a variety of normal cellular functions. They are oncogenically activated in a significant fraction of tumors.[supplied by OMIM]
      Gene Symbol
      • K-Ras
      • Ki-Ras
      • K-Ras2
      • Kras-2
      • p21B
      • KRAS
      • RASK2
      • HRAS
      • HA_RAS
      • N-RAS
      • H-RAS
      • NRAS
      • NRAS1
      • ALPS4
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
      Enzyme regulation:Alternate between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).
      SIZE: 189 amino acids; 21,656 Da
      SUBUNIT: Interacts with PHLPP (By similarity).
      SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side.
      Involvement in disease:
      Defects in KRAS are a cause of acute myelogenous leukemia (AML) [MIM:601626]. AML is a malignant disease in which hematopoietic precursors are arrested in an early stage of development.

      Defects in KRAS are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:607785]. JMML is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and 2% of leukemia. It is characterized by leukocytosis with tissue infiltration and in vitro hypersensitivity of myeloid progenitors to granulocyte-macrophage colony stimulating factor.

      Defects in KRAS are the cause of Noonan syndrome 3 (NS3) [MIM:609942]. Noonan syndrome (NS) [MIM:163950] is a disorder characterized by dysmorphic facial features, short stature, hypertelorism, cardiac anomalies, deafness, motor delay, and a bleeding diathesis. It is a genetically heterogeneous and relatively common syndrome, with an estimated incidence of 1 in 1000-2500 live births. Rarely, NS is associated with juvenile myelomonocytic leukemia (JMML). NS3 inheritance is autosomal dominant.

      Defects in KRAS are a cause of cardiofaciocutaneous syndrome (CFC syndrome) [MIM:115150]; also known as cardio-facio-cutaneous syndrome. CFC syndrome is characterized by a distinctive facial appearance, heart defects and mental retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices. The inheritance of CFC syndrome is autosomal dominant.

      KRAS mutations are involved in cancer development.
      Molecular Weight21 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8ºC from date of receipt.
      DO NOT FREEZE
      Packaging Information
      Material Size200 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      16-321 04053252751271

      Documentation

      Anti-Ras Magnetic Bead Conjugate Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Ras Magnetic Bead Conjugate Antibody Certificates of Analysis

      TitleLot Number
      Anti-Ras Magnetic Bead Conjugate 2487770
      Anti-Ras Magnetic Bead Conjugate 2483268
      Anti-Ras Magnetic Bead Conjugate - 2051389 2051389
      Anti-Ras Magnetic Bead Conjugate - 2377629 2377629
      Anti-Ras Magnetic Bead Conjugate - 2514586 2514586
      Anti-Ras Magnetic Bead Conjugate - 3201051 3201051
      Anti-Ras Magnetic Bead Conjugate - 3290995 3290995
      Anti-Ras Magnetic Bead Conjugate - 3561574 3561574
      Anti-Ras Magnetic Bead Conjugate - 3610577 3610577
      Anti-Ras Magnetic Bead Conjugate - 3759064 3759064
      Show more

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies