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MABT123 Anti-Pirh2 Antibody, clone 11G8.1

Anti-Pirh2 Antibody, clone 11G8.1 is a highly specific mouse monoclonal antibody & that targets Pirh2 & has been tested in western blotting.

Anti-Pirh2 Antibody, clone 11G8.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Cell Structure Research Sub-Category: ECM Proteins Gene Symbol: RCHY1, ARNIP, CHIMP, PIRH2, RNF199, ZNF363 UniProt Number: Q96PM5
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MABT123
100 µg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABT123
      DescriptionAnti-Pirh2 Antibody, clone 11G8.1
      Alternate Names
      • RING finger and CHY zinc finger domain-containing protein 1
      • Androgen receptor N-terminal-interacting protein
      • CH-rich-interacting match with PLAG1
      • E3 ubiquitin-protein ligase Pirh2
      • RING finger protein 199
      • Zinc finger protein 363
      • p53-induced RING-H2 protein
      • hPirh2
      Background InformationPirh2, also known as Androgen receptor N-terminal-interacting protein or CH-rich-interacting match with PLAG1 or E3 ubiquitin-protein ligase Pirh2 or RING finger protein 199 or Zinc finger protein 363 or p53-induced RING-H2 protein (Pirh2), encoded by the gene RCHY1/ARNIP/CHIMP/PIRH2/RNF199/ZNF363, is an E3 ubiquitin ligase protein that mediates the E3-dependent ubiquitination and proteasomal degradation of a number of important signaling and DNA methylation proteins including p53/TP53, p73, HDAC1 and CDKN1B. Pirh2 also monoubiquitinates the translesion DNA polymerase POLH and contributes to the regulation of the cell cycle progression. Additionally, Pirh2 increases androgen receptor transcription factor activity as well and Interacts with AR, p53/TP53, MDM2, HDAC1, KAT5, PLAG1, PLAGL2, CDKN1B, COPE, UBE2D2 and GORAB/NTKLBP1 proteins. Pirh2 is localized to the cytoplasm and nucleus, and can be found in nucleus speckles. Pirh2 is expressed in all cell types examined and is up-regulated during the S phase of the cell cycle. Pirh2 is expressed at low levels during G phase.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Pirh2 Antibody, clone 11G8.1 is a highly specific mouse monoclonal antibody & that targets Pirh2 & has been tested in western blotting.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to human Pirh2.
      Clone11G8.1
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • RCHY1
      • ARNIP
      • CHIMP
      • PIRH2
      • RNF199
      • ZNF363
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~30 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in H1299 cell lysate.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected Pirh2 in 10 µg of H1299 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABT123 04053252936005