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MABN1544 Anti-IP3R3 Antibody, clone 6G12.1

Anti-IP3R3 Antibody, clone 6G12.1, Cat. No. MABN1544, is a highly specific mouse monoclonal antibody that targets ITPR3 and has been tested in Western Blotting.

Anti-IP3R3 Antibody, clone 6G12.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Gene Symbol: ITPR3 UniProt Number: Q14573
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MABN1544
200 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN1544
      DescriptionAnti-IP3R3 Antibody, clone 6G12.1
      Alternate Names
      • Inositol 1
      • 4
      • 5-trisphosphate receptor type 3
      • InsP3R3
      • IP3 receptor isoform 3
      • IP3R 3
      • Type 3 inositol 1
      • 4
      • 5-trisphosphate receptor
      • Type 3 InsP3 receptor
      Background InformationInsP3R3, IP3 receptor isoform 3, IP3R 3, Type 3 inositol 1,4,5-trisphosphate receptor, Type 3 InsP3 receptor) is encoded by the ITPR3 gene (Gene ID 3710) in human. The inositol 1,4,5-trisphosphate (InsP3) receptors, InsP3R1, InsP3R2, and InsP3R3, play an important role in maintaining normal epithelial secretory function by mediating intracellular Ca2+ release. InsP3R3 is the major isoform in hepatic bile ducts, where it is concentrated along the subapical portion of the ER and regulates bicarbonate (HCO3 ) and chloride (Cl ) secretion into the bile. Wherease hepatocytes express mainly InsP3R2 that is involved in modulating the secretion of bile solutes. A loss of InsP3R3 expression in cholangiocytes is found in primary biliary cirrhosis (PBC), an autoimmune liver disease characterized by the loss of bile ducts and impaired bile secretion. Likewise, InsP3R3 and InsP3R2 double knockout mice are reported to exhibit severe defects of pancreatic zymogen secretion. Human InsP3R3 is a 6-transmembrane (a.a. 2203-2223, 2236-2256, 2265-2285, 2326-2346, 2369-2389, 2497-2517) ER membrane protein, having both its N- and C-terminal ends (a.a. 1-2202 and 2518-2671) exposed at the cytoplasmic side. The N-terminal cytoplasmic region contains five MIR (Mannosyltransferase, InsP3R, RyR) domains (a.a. 113-173, 174-224, 232-288, 295-372, 378-434) and the InsP3-binding sites (a.a. 266-270, 507-510, 567-569).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse IgG2b in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-IP3R3 Antibody, clone 6G12.1, Cat. No. MABN1544, is a highly specific mouse monoclonal antibody that targets ITPR3 and has been tested in Western Blotting.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenGST-tagged recombinant human IP3R3 (IP3 Receptor 3) N-terminal cytoplasmic domain fragment.
      Clone6G12.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 6G12.1 targets an epitope in the C-terminal half of human IP3R3 (IP3 Receptor 3) N-terminal cytoplasmic domain.
      IsotypeIgG2bκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ITPR3
      Purification MethodProtein G purified.
      UniProt Number
      Molecular Weight~260 kDa observed. 304.1 kDa calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HeLa cell lysate.

      Western Blotting Analysis: A 1:500 dilution of this antibody detected IP3R3 (IP3 Receptor 3) in 10 µg of HeLa cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size200 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABN1544 04054839057885