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ABF28 Anti-HAVcr-1 Antibody

Detect HAVcr-1 using this Anti-HAVcr-1 Antibody validated for use in western blotting & flow cytometry.

Anti-HAVcr-1 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Research Sub-Category: Inflammation & Autoimmune Mechanisms Gene Symbol: HAVCR1, KIM1, TIM1, TIMD1 UniProt Number: Q96D42
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ABF28
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, FCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABF28
      DescriptionAnti-HAVcr-1 Antibody
      Alternate Names
      • Hepatitis A virus cellular receptor 1
      • HAVcr-1
      • Kidney injury molecule 1
      • KIM-1
      • T-cell immunoglobulin and mucin domain-containing protein 1
      • TIMD-1
      • T-cell immunoglobulin mucin receptor 1
      • TIM
      • TIM-1
      • T-cell membrane protein 1
      Background InformationT-cell immunoglobulin and mucin domain-containing protein 1 (TIMD-1, TIM-1, TIM, TIM1, TIMD1), also known as Hepatitis A virus cellular receptor 1 (HAVcr-1) and Kidney injury molecule 1(KIM-1, KIM1), may play an important role in T-helper cell development and the regulation of asthma and allergic diseases. In the case of human hepatitis A virus (HHAV) infection, HAVcr-1 functions as a cell-surface receptor for the virus, through which the hepatitis A virus can gain entry into a cell. Additional evidence implies that it may play a role in kidney injury and repair. HAVcr-1 is widely expressed, with highest levels in kidney and testis. It is also expressed by activated CD4+ T-cells during the development of helper T-cells responses. Furthermore, HAVcr-1 is expressed on T helper 2 (Th2) cells of the immune system, and following the binding of its natural ligand TIM-4, stimulates T cell expansion and cytokine production in response to viral challenge.
      References
      Product Information
      FormatAffinity Purified
      HS Code3002 15 90
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect HAVcr-1 using this Anti-HAVcr-1 Antibody validated for use in western blotting & flow cytometry.
      Key Applications
      • Western Blotting
      • Flow Cytometry
      Application NotesFlow Cytometry Analysis: 1 µg from a representative lot detected HAVcr-1 in 1X10E6 769-P cells.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human HAVcr-1.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      Species Reactivity NoteHuman. Predicted to react with Baboon, Chimpanzee and Primate based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • HAVCR1
      • KIM1
      • TIM1
      • TIMD1
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~59 kDa observed. Uniprot describes a molecular weight at 38 kDa. However, this protein has been observed at ~59 kDa (Thompson, P., et al. (1998). J Virol. 72(5):3751-3761.).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human spleen tissue lysate.

      Western Blotting Analysis: 1 µg/mL of this antibody detected HAVcr-1 in 10 µg of human spleen tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABF28 04053252961144

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies