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ABE1351 Anti-GATA-6 Antibody

This Anti-GATA-6 Antibody is validated for use in Western Blotting and Immunocytochemistry for the detection of GATA-6.

Anti-GATA-6 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Transcription Factors Gene Symbol: GATA6 UniProt Number: Q92908
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ABE1351
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, ICCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABE1351
      DescriptionAnti-GATA-6 Antibody
      Alternate Names
      • Transcription factor GATA-6
      • GATA-binding factor 6
      Background InformationGATA-6 is a developmental transcriptional activator important in terminal differentiation and proliferation of cells destined to be associated with the heart, gut and gut related tissues and organs. GATA-6 works in concert with SEMA3C and PLXNA2 transcription factors and regulates the expression of their target genes. GATA-6 is particularly important in heart development as a number of genetic mutations within GATA-6 give rise to defective syndromes involving the heart or the vessels of the heart. Interestingly, recent research into pulmonary hypertension disease in adults points to a critical role of GATA-6 expression in endothelial cells lining the blood vessels. Healthy blood vessels express GATA-6 very strongly but expression is lost during vascular injury and markedly down regulated in the endothelial cells found in diseased vessels. Because GATA-6 is a direct transcriptional regulator or important vascular proteins such as endothelin-1 receptor, endothelial nitric oxide synthase, and cytokines such as Fractalkine, GATA-6’s role in modulating the affects of pulmonary hypertension and other vascular syndromes is a subject of much research.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing PBS with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-GATA-6 Antibody is validated for use in Western Blotting and Immunocytochemistry for the detection of GATA-6.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesImmunocytochemistry Analysis: A representative lot of this antibody has been reported to detect GATA-6 in HeLa, 293T, Capan-2, and SH-SY5Ycells.
      Biological Information
      ImmunogenSet of 3 peptides designed against isoform 1 located between position 250-500). Note that peptide sequences used are also present in the isoform 2.
      EpitopeRegion between amino acid positions 250-500.
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityRecognizes GATA-6
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • GATA6
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~ 62 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in PC3 cell lysate.

      Western Blotting Analysis: A 2 µg/mL dilution of this antibody detected GATA-6 in PC3cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABE1351 04055977052862