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07-1801 Anti-G3BP1 Antibody

Anti-G3BP1 Antibody detects level of G3BP1 & has been published & validated for use in WB & IP.

Anti-G3BP1 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: RNA Binding Protein (RBP) Gene Symbol: EC 3.6.1, G3BP, G3BP-1 , HDH-VIII UniProt Number: Q13884
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07-1801
100 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, H, RWB, IPRbSerumPolyclonal Antibody
      Description
      Catalogue Number07-1801
      DescriptionAnti-G3BP1 Antibody
      Alternate Names
      • ATP-dependent DNA helicase VIII
      • GAP SH3 domain-binding protein 1
      • GAP binding protein
      • GTPase activating protein (SH3 domain) binding protein 1
      • Ras-GTPase-activating protein SH3-domain-binding protein
      • RasGAP-associated endoribonuclease G3BP
      Background InformationG3BP1 (Ras-GTPase activating protein SH3-domain binding protein 1) directly associates with SH3 domains of GTPase activating proteins (GAPs). It was first discovered by its binding to RasGAP. G3BPs have been shown to be involved in a number of mitogenic signaling pathways. G3BP1 is also known to be over expressed in many human cancers (Kim, 2007) and its expression appears to be inversely correlated with PTEN expression (Kim, 2007). Interestingly, G3BP1, along with G3BP2, has been shown to bind to the C-terminus of p53, playing a crucial role in its activity (Kim, 2007). Furthermore, the G3BPs have two traditional RNA binding motifs.
      References
      Product Information
      FormatSerum
      Control
      • HeLa cell lysates.
      PresentationRabbit polyclonal serum with 0.05% NaN3.
      Quality LevelMQ100
      Applications
      ApplicationAnti-G3BP1 Antibody detects level of G3BP1 & has been published & validated for use in WB & IP.
      Key Applications
      • Western Blotting
      • Immunoprecipitation
      Biological Information
      ImmunogenSynthetic peptide corresponding to C-terminal region of human G3BP1.
      EpitopeC-terminus
      HostRabbit
      SpecificityThis antibody detects G3BP1 at its C-terminal region.
      Species Reactivity
      • Mouse
      • Human
      • Rat
      Species Reactivity NoteHuman and Mouse. Not tested on other species. Rat expected to react as immunogen is 100% homologous.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It binds specifically to the Ras-GTPase-activating protein by associating with its SH3 domain. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq]
      Gene Symbol
      • EC 3.6.1
      • G3BP
      • G3BP-1
      • HDH-VIII
      UniProt Number
      UniProt SummaryFUNCTION: Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex.

      SUBUNIT STRUCTURE: Monomer and homodimer Probable. Interacts with the other members of the syntrophin family SNTA1 and SNTB2; with the sodium channel proteins SCN4A and SCN5A By similarity. Interacts with the viral HTLV-1 TAX protein and with dystrophin protein DMD and related proteins DTNA and UTRN.

      SUBCELLULAR LOCATION: Cell membrane › sarcolemma; Peripheral membrane protein; Cytoplasmic sideBy similarity. Cell junctionBy similarity. Cytoplasm › cytoskeletonBy similarity. Note= In skeletal muscle, it localizes at the cytoplasmic side of the sarcolemmal membrane and at neuromuscular junctions By similarity.

      TISSUE SPECIFICITY:Ubiquitous. Ref.1

      DOMAIN: The PH 1 domain mediates the oligomerization in a calcium dependent manner By similarity.

      The PDZ domain binds to the last three or four amino acids of ion channels and receptor proteins. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane By similarity.

      The SU domain binds calmodulin in a calcium-dependent manner By similarity.

      PTM: Phosphorylated by CaM-kinase II By similarity.

      SIMILARITY:Belongs to the syntrophin family.

      Contains 1 PDZ (DHR) domain.

      Contains 2 PH domains.

      Contains 1 SU (syntrophin unique) domain.
      Molecular Weight68 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by western blot on HeLa cell lysates.

      Western Blot Analysis:
      1:1,000 dilution of this antibody was used to detect G3BP1 in HeLa, 293T and S10 cell lysates.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20ºC from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      07-1801 04053252674853