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ABS1036 Anti-FMO3 Antibody

Detect FMO3 using this Anti-FMO3 Antibody validated for use in Western Blotting, Immunohistochemistry.

Anti-FMO3 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Toxicology & Drug Resistance Gene Symbol: FMO3, FMOII, TMAU UniProt Number: P31513
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ABS1036
200 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IHCRbSerumPolyclonal Antibody
      Description
      Catalogue NumberABS1036
      DescriptionAnti-FMO3 Antibody
      Alternate Names
      • Dimethylaniline monooxygenase [N-oxide-forming] 3
      • Dimethylaniline oxidase 3
      • FMO form 2
      • FMO 3
      • FMO II
      • Hepatic flavin-containing monooxygenase 3
      • Trimethylamine monooxygenase
      Background InformationDimethylaniline monooxygenase [N-oxide-forming] 3 (EC 1.14.13.8; EC 1.14.13.148; UniProt P31513; also known as Dimethylaniline oxidase 3, FMO form 2, FMO 3, FMO II, Hepatic flavin-containing monooxygenase 3, Trimethylamine monooxygenase) is encoded by the FMO3 (also known as FMOII, TMAU) gene (Gene ID 2328) in human. Flavin-containing mono-oxygenases (FMOs) constitute a family of microsomal chemical- and drug-metabolizing enzymes, with FMO3 being a major form in adult mouse and human liver. FMO3 is responsible for N-oxidation of a malodorous metabolite, trimethylamine (TMA), to the non-odorous trimethylamine N-oxide (TMAO). FMO3 mutations cause trimethylaminuria (TMAU or Fish odor syndrome), a rare inherited disorder due to decreased metabolism of dietary-derived TMA. More than 300 single nucleotide polymorphisms of the human FMO3 have been reported and over 40 of these polymorphisms have been linked to TMAU. 17β-estradiol-dependent ERα activation is reported to play a fundamental role in the regulation of FMO3 gene transcription.
      References
      Product Information
      FormatSerum
      PresentationRabbit polyclonal serum with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect FMO3 using this Anti-FMO3 Antibody validated for use in Western Blotting, Immunohistochemistry.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected FMO3 in human liver tissue.
      Biological Information
      ImmunogenLinear peptide corresponding to an internal sequence from the N-terminal half of human FMO3.
      EpitopeInternal (N-terminal half).
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      Species Reactivity
      • Human
      Species Reactivity NoteHuman. Predicted to react with Chimpanzee based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • FMO3
      • FMOII
      • TMAU
      Purification MethodUnpurified
      UniProt Number
      Molecular Weight~55 kDa observed. 59.96 kDa calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human liver microsomal tissue lysate.

      Western Blotting Analysis: A 1:500 dilution of this antibody detected FMO3 in 10 µg of human liver microsomal tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size200 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABS1036 04055977315745