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ABN470 Anti-EPAC1 Antibody

Anti-EPAC1 Antibody is a highly specific rabbit polyclonal antibody, that targets Epac & has been tested in western blotting & IHC.

Anti-EPAC1 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience Gene Symbol: RAPGEF3, CGEF1, EPAC, EPAC1 UniProt Number: O95398
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ABN470
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, RWB, IHCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABN470
      DescriptionAnti-EPAC1 Antibody
      Alternate Names
      • Rap guanine nuclear exchange factor 3
      • RAPGEF3
      • cAMPGEF-I
      • bcm910
      • cAMP-GEFI
      • Exchange factor directly activated by cAMP
      • cAMP-regulated guanine nucleotide exchange factor I
      • EPAC1
      Background InformationExchange protein directly activated by cAMP 1 (EPAC1) is also known as Rap guanine nuclear exchange factor 3 and cAMPGEF-I. EPAC1 is a guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases which are activated through cAMP binding. EPAC1 couples cAMP production to the activation of the Ras family GTPase, Rap. Activation of Rap drives several cellular processes such as integrin-mediated cell adhesion, vascular endothelial barrier formation, and cardiac myocyte gap junction formation. EPAC1 is part of a signaling complex in which it activates the PI3K gamma complex, which is involved in angiogenesis. EPAC1 may also regulate ion channel formation, intracellular Ca++ signaling, ion transporter activity, and exocytosis. EPAC1 is widely expressed, especially in brain, heart, kidney, pancreas, spleen, ovary, thyroid and spinal cord.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Rat skeletal muscle tissue lysate
      PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-EPAC1 Antibody is a highly specific rabbit polyclonal antibody, that targets Epac & has been tested in western blotting & IHC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected EPAC1 in human kidney, thalamus, and cerebellum tissues.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human EPAC1.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      • Rat
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • RAPGEF3
      • CGEF1
      • EPAC
      • EPAC1
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~103 kDa observed. Uncharacterized bands may appear in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in rat skeletal muscle tissue lysate.

      Western Blotting Analysis: 1 µg/mL of this antibody detected EPAC1 in 15 µg of rat skeletal muscle tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABN470 04053252923494