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AB10000 Anti-CHIP/STUB1 Antibody

This Anti-CHIP/STUB1 Antibody is validated for use in ELISA, WB for the detection of CHIP/STUB1.

Anti-CHIP/STUB1 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Protein Trafficking Research Sub-Category: Ubiquitin & Ubiquitin Metabolism Gene Symbol: STUB1, SDCCAG7, NY-CO-7, HSPABP2, UBOX1, CHIP UniProt Number: Q9UNE7
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AB10000
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, ChpELISA, WBGtAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB10000
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-CHIP/STUB1 Antibody
      Alternate Names
      • CHIP
      • STUB1
      Background InformationU box domain E3 ubiquitin ligase. CHIP E3 controls both the association of Hsp70/Hsp90 chaperones with ErbB2 and the down-regulation of ErbB2 induced by inhibitors of Hsp90. CHIP-induced degradation was observed for mutant and wild-type p53, which transiently associate with molecular chaperones Hsc70 and Hsp90 and can be diverted onto a degradation pathway through this association. Also, CHIP can interact with the Smad1/Smad4 proteins and block BMP signal transduction through the ubiquitin-mediated degradation of Smad proteins.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Positive Control: Highly expressed in brain, heart, skelatal muscle, pancreas and placenta. Weak expression in kidney, liver and lung.
      PresentationTris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-CHIP/STUB1 Antibody is validated for use in ELISA, WB for the detection of CHIP/STUB1.
      Key Applications
      • ELISA
      • Western Blotting
      Biological Information
      ImmunogenPeptide with sequence DAFISENGWVEDY, from the C-terminus of the protein sequence according to NP_005852.
      HostGoat
      Species Reactivity
      • Human
      • Chimpanzee
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • STUB1
      • SDCCAG7
      • NY-CO-7
      • HSPABP2
      • UBOX1
      • CHIP
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9UNE7 # Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Has E3 ubiquitin-protein ligase activity and targets misfolded chaperone substrates towards proteasomal degradation. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation.
      SIZE: 303 amino acids; 34856 Da
      SUBUNIT: Interacts with BAG2, and with the E2 ubiquitin conjugating enzymes UBE2D1, UBE2D2 and UBE2D3. Interacts with the C-terminal domains of HSPA8 and HSPA1A. Detected in a ternary complex containing STUB1, HSPA1A and HSPBP1.
      SUBCELLULAR LOCATION: Cytoplasm.
      TISSUE SPECIFICITY: Highly expressed in skeletal muscle, heart, pancreas, brain and placenta. Detected in kidney, liver and lung.
      PTM: Auto-ubiquitinated (in vitro). & Phosphorylated upon DNA damage, probably by ATM or ATR.
      DISEASE:SwissProt: Q9UNE7 # Antibodies against STUB1 are found in patients with chronic lymphocytic leukemia (CLL) and in colorectal cancer patients.
      SIMILARITY: SwissProt: Q9UNE7 ## Contains 3 TPR repeats. & Contains 1 U-box domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at -20°C.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB10000 04053252325144

      Documentation

      Anti-CHIP/STUB1 Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-CHIP/STUB1 Antibody Certificates of Analysis

      TitleLot Number
      GOAT ANTI-STUB1/CHIP POLYCLONAL ANTIBODY - 2344416 2344416
      GOAT ANTI-STUB1/CHIP POLYCLONAL ANTIBODY - 4090669 4090669
      GOAT ANTI-STUB1/CHIP POLYCLONAL ANTIBODY -2669987 2669987
      GOAT ANTI-STUB1/CHIP POLYCLONAL ANTIBODY -2677243 2677243
      GOAT ANTI-STUB1/CHIP POLYCLONAL ANTIBODY -2768140 2768140

      References

      Reference overviewPub Med ID
      CHIP is a U?box?dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiiquitylation.
      Jiang J., et al.
      J Biol Chem., 276(46):42938?44 (2001 )  2001

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